GENE SPECIFIC DNA REPAIR THROUGHOUT THE CELL CYCLE

整个细胞周期的基因特异性 DNA 修复

• 批准号: 6160481
• 负责人: V A BOHR
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6160481
• 关键词: DNA damage; DNA repair; DNA replication; adduct; cell cycle; cell senescence; genetic transcription

Our studies are designed to understand the interrelationships between DNA metabolism, specifically DNA damage and its repair, and the cell cycle progression in mammalian cells. We are particularly interested in characterizing the gene- and strand-specific patterns of repair of various adducts in the different phases of the cell cycle; this will allow us to correlate DNA repair processes with transcription, replication, and mutagenesis. Determination of phase-specific repair processes will also shed light on the possible accumulation and distribution of DNA damage in non-cycling (differentiated and senescent) cells.

我们的研究旨在了解 DNA 之间的相互关系 新陈代谢，特别是 DNA 损伤及其修复，以及细胞周期 哺乳动物细胞中的进展。 我们特别感兴趣的是 表征基因和链特异性修复模式 细胞周期不同阶段的各种加合物；这将 使我们能够将 DNA 修复过程与转录关联起来， 复制和突变。 特定阶段修复的确定 过程还将揭示可能的积累和 非循环（分化和衰老）中 DNA 损伤的分布 细胞。