GENE SPECIFIC DNA REPAIR THROUGHOUT THE CELL CYCLE

整个细胞周期的基因特异性 DNA 修复

• 批准号: 3745541
• 负责人: V A BOHR
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3745541
• 关键词: DNA damage; DNA repair; DNA replication; adduct; cell cycle; cell senescence; genetic transcription; integrins; nucleic acid metabolism

Our studies are designed to understand the interrelationships between DNA metabolism, specifically DNA damage and its repair, and the cell cycle in mammalian cells. We are particularly interested in characterizing the gene- and strand-specific patterns of repair of various adducts in the different phases of the cell cycle; this will allow us to correlate DNA repair processes with transcription, replication, and mutagenesis. Determination of phase-specific repair processes will also shed light on the possible accumulation and distribution of DNA damage in non-cycling (differentiated and senescent) cells.

我们的研究旨在了解DNA之间的相互关系 新陈代谢，特别是DNA损伤及其修复，以及细胞周期 在哺乳动物细胞中。我们特别感兴趣的是描述 不同加合物修复的基因和链特异性模式 细胞周期的不同阶段；这将使我们能够将DNA 通过转录、复制和突变修复过程。 确定特定阶段的维修流程也将有助于了解 非循环运动中DNA损伤的可能积累和分布 (分化和衰老)细胞。