PROSTATE CARCINOMA--INVASION AND METASTASIS FACTORS

我们把病理学的经验和技术结合起来， 前列腺问题的细胞生物学和分子生物学 致癌。使用人类组织样本、前列腺细胞系和 正常和转基因细胞系的实验注射 免疫缺陷小鼠，我们将探索细胞外的作用 基质蛋白、细胞骨架、质膜相关整合素、 金属蛋白酶的多基因家族及其组织特异性 抑制剂。这项研究的长期目标是定义关键 导致前列腺癌扩散的事件使标准 可能被定义为允许准确地识别生物学上的 更具侵袭性的肿瘤。这项研究的好处是：1) 加深对肿瘤侵袭的基本生物学的了解，2)a 更理性地选择治疗方法，以及3)发现 旨在防止入侵的新方法。

We have focused the combined experiences and techniques of pathology, cell biology and molecular biology on the problem of prostate carcinogenesis. Using human tissue specimens, prostate cell lines, and normal and transfected cell lines injected experimentally into immunodeficient mice, we will explore the roles of the extracellular matrix proteins, cytoskeleton, the plasma membrane associated integrins, and the multigene family of metalloproteinases and their tissue specific inhibitors. The long term goal of the research is to define the critical events responsible for prostatic carcinoma dissemination so that criteria might be defined to allow accurate identification of the biologically more aggressive tumors. The benefit of this research would be: 1) an increased understanding of the basic biology of neoplastic invasion, 2) a more rational approach to selection of therapy, and 3) the discovery of new approaches aimed at preventing invasion.