Tissue Acquisition

9.1.11组织获取和细胞/分子共享服务 组织获取和细胞/分子分析共享服务(TACMASS)执行两个主要功能 亚利桑那癌症中心(AZCC)： 1.组织采集： TACMASS收集、保存和储存从AZCC手术患者同意的患者那里获得的生物标本。存入银行 冰冻和福尔马林固定、石蜡包埋组织、基因组DNA、血浆、血清和尿液 带有临床和病理信息的注释，使调查人员能够查询数据库以识别 可能对亚利桑那大学机构审查委员会的分析有用的适当生物谱系 (IRB)批准的协议。总体目标是为癌症研究人员提供访问高密度信息库的途径 精心收集和注释高质量的人类肿瘤组织和体液，以供当前和未来的翻译 癌症方面的研究。 2.组织和细胞的分子和病理分析： TACMASS为AZCC研究人员提供了使用最先进的分子分析工具的技术 常规组织学，免疫组织化学。激光捕获显微切割与组织构建 微阵列。TACMASS协助研究人员进行实验设计和建立组织学评分 策略，并咨询调查人员，以分析和解释病理结果在整个背景下 整个项目。 TACMASS的主要目标之一是为所有五个项目的AZCC研究人员提供高质量 实验数据的病理分析和解释。该服务由Ray Nagle医学博士指导。 联席主任是Achyut Bhattacharyya医学博士和郑文新医学博士。该服务配备了四项研究 专家。

9.1.11 TISSUE ACQUISITION AND CELLULAR/MOLECULAR SHARED SERVICE The Tissue Acquistion and Cellular/Molecular Analysis Shared Service (TACMASS) performs two main functions for the Arizona Cancer Center (AZCC): 1. Tissue Acquisition: TACMASS cpilects, preserves, and banks biospecimens obtained from consented AZCC surgical patients. Banked bibspeciniens (frozen and formalin fixed, paraffin embedded tissues, genomic DNA, plasma, serum and urine) are annotated with clinical and pathological infomiation, which enables investigators to query a database to identify appropriate biospecimens that may be useful for analysis under University of Arizona Institutional Review Board (IRB) approved protocols. The overall goal is to provide cancer researchers with access to a repository of high quality, carefully collected and annotated human tumor tissue and body fluids for current and future translational studies in cancer. 2. Molecular and pathological analysis of tissues and cells: TACMASS provides AZCC researchers with access to state of the art molecular analytical tools using techniques of routine histology, immunohistochemistry. Laser Capture Microdissection, and the construction of Tissue Microarrays. TACMASS assists researchers with experimental design and the establishment of histological scoring strategies, and consults with investigators to analyze and interpret pathological findings in the overall context of the whole project. One ofthe primary goals of TACMASS is to provide AZCC researchers from all five programs with high quality pathological analysis and interpretation of experimental data. The Service is directed by Ray Nagle, M.D., Ph.D. Co-Directors are Achyut Bhattacharyya M.D. and Wenxin Zheng, M.D. The service is staffed with four research specialists.