Prostate Carcinoma: Invasion and Metastasis Factors

描述（由申请人提供）：我们将病理学、细胞生物学和分子生物学的经验和技术结合起来，研究前列腺癌的发生问题。利用人体组织标本、前列腺细胞系、正常细胞系和转染细胞系实验注射免疫缺陷小鼠和转基因小鼠，我们将探讨细胞外基质蛋白、细胞表面整合素和多基因钙粘蛋白家族的作用。这项研究的长期目标是确定导致前列腺癌扩散的关键事件，以便确定标准，以便准确识别生物学上更具侵袭性的肿瘤。

DESCRIPTION (provided by applicant): We have focused the combined experiences and techniques of pathology, cell biology and molecular biology on the problem of prostate carcinogenesis. Using human tissue specimens, prostate cell lines and normal and transfected cell lines injected experimentally into immunodeficient mice and transgenic mice, we will explore the roles of the extracellular matrix proteins, cell surface integrins and the multigene family of cadherins. The long-term goal of this research is to define the critical events responsible for prostatic carcinoma dissemination so that criteria might be defined to allow accurate indentification of the biologically more aggressive tumors. The benefit of this research is: 1. An increased understanding of the basic biology of neoplastic invasion. 2. A more rational approach to therapy selection. 2. The discovery of new approaches aimed at preventing invasion.