PROSTATE CARCINOMA--INVASION AND METASTASIS FACTORS

我们专注于结合病理学，细胞学， 生物学和分子生物学在前列腺癌问题上的研究。 使用人体组织标本，前列腺细胞系，正常和 实验性地将转染的细胞系注射到免疫缺陷小鼠中， 我们将探讨细胞外基质蛋白，细胞， 表面整合素和金属蛋白酶的多基因家族。的 研究的长期目标是确定关键事件 导致前列腺癌扩散，因此标准可能 被定义为允许准确识别生物学上更多的 侵袭性肿瘤这项研究的好处是：1）增加 了解肿瘤侵袭的基本生物学，2）更多 合理的方法来选择治疗，和3）发现新的 目的是防止入侵。

We have focused the combined experiences and techniques of pathology, cell biology, and molecular biology on the problem of prostrate carcinogenesis. Using human tissue specimens, prostrate cell lines, and normal and transfected cell lines injected experimentally into immunodeficient mice, we will explore the roles of the extracellular matrix proteins, cell surface integrins, and the multigene family of metalloproteinases. The long term goal of the research is to define the critical events responsible for prostatic carcinoma dissemination so that criteria might be defined to allow accurate identification of the biologically more aggressive tumors. The benefit of this research would be: 1) an increased understanding of the basic biology of neoplastic invasion, 2) a more rational approach to selection of therapy, and 3) the discovery of new approaches aimed at prevention invasion.