PROSTATE CARCINOMA--INVASION AND METASTASIS FACTORS

前列腺癌——侵袭和转移因素

• 批准号: 6171886
• 负责人: RAYMOND B NAGLE
• 金额: $ 86万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-05-14 至 2002-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6171886
• 关键词: molecular oncology; neoplasm /cancer invasiveness; prostate neoplasms

We have focused the combined experiences and techniques of pathology, cell biology, and molecular biology on the problem of prostrate carcinogenesis. Using human tissue specimens, prostrate cell lines, and normal and transfected cell lines injected experimentally into immunodeficient mice, we will explore the roles of the extracellular matrix proteins, cell surface integrins, and the multigene family of metalloproteinases. The long term goal of the research is to define the critical events responsible for prostatic carcinoma dissemination so that criteria might be defined to allow accurate identification of the biologically more aggressive tumors. The benefit of this research would be: 1) an increased understanding of the basic biology of neoplastic invasion, 2) a more rational approach to selection of therapy, and 3) the discovery of new approaches aimed at prevention invasion.

我们专注于病理学、细胞学的经验和技术的结合 生物学，和分子生物学关于便秘致癌的问题。 使用人体组织标本、俯卧细胞系以及正常和 通过实验将转基因细胞系注射到免疫缺陷小鼠体内， 我们将探索细胞外基质蛋白、细胞 表面整合素，以及金属蛋白酶的多基因家族。这个 这项研究的长期目标是定义关键事件 负责前列腺癌的扩散，因此标准可能 被定义为允许准确识别生物学上更多的 侵袭性肿瘤。这项研究的好处是：1)增加了 了解肿瘤侵袭的基本生物学，2)更多 合理选择治疗方法；3)新的发现 旨在防止入侵的方法。