PROSTATE CARCINOMA--INVASION AND METASTASIS FACTORS

前列腺癌——侵袭和转移因素

• 批准号: 2551495
• 负责人: RAYMOND B NAGLE
• 金额: $ 5.67万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-05-14 至 1997-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2551495
• 关键词: extracellular matrix proteins; metalloendopeptidases; metastasis; molecular oncology; neoplasm /cancer invasiveness; prostate neoplasms; tissue inhibitor of metalloproteinases

We have focused the combined experiences and techniques of pathology, cell biology and molecular biology on the problem of prostate carcinogenesis. Using human tissue specimens, prostate cell lines, and normal and transfected cell lines injected experimentally into immunodeficient mice, we will explore the roles of the extracellular matrix proteins, cytoskeleton, the plasma membrane associated integrins, and the multigene family of metalloproteinases and their tissue specific inhibitors. The long term goal of the research is to define the critical events responsible for prostatic carcinoma dissemination so that criteria might be defined to allow accurate identification of the biologically more aggressive tumors. The benefit of this research would be: 1) an increased understanding of the basic biology of neoplastic invasion, 2) a more rational approach to selection of therapy, and 3) the discovery of new approaches aimed at preventing invasion.

我们集中了病理学的经验和技术， 前列腺问题的细胞生物学和分子生物学 致癌作用 使用人体组织标本，前列腺细胞系， 正常和转染的细胞系实验性地注射到 免疫缺陷小鼠，我们将探讨细胞外的作用， 基质蛋白，细胞骨架，质膜相关整合素， 金属蛋白酶的多基因家族及其组织特异性 抑制剂的 这项研究的长期目标是确定关键的 导致前列腺癌扩散的事件， 可以被定义为允许准确识别生物学上的 更有攻击性的肿瘤 这项研究的好处是：1）一个 增加对肿瘤侵袭的基础生物学的理解，2）a 更合理的方法来选择治疗，和3）发现， 旨在防止入侵的新方法。