THEORETICAL INVESTIGATIONS OF GENETIC IDENTITY AND DISEQUILIBRIA

遗传同一性和不平衡的理论研究

• 批准号: 3774891
• 负责人: J C STEPHENS
• 金额: --
• 依托单位: DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3774891
• 关键词: biochemical evolution; ethnic group; genetic polymorphism; human data; human genetic material tag; human population genetics; linkage mapping; phenotype

Our research has focussed on the feasibility of mapping genes through linkage disequilibrium. Linkage disequilibrium is manifested at the population level and thus has certain advantages over mapping genes by pedigree analysis. In particular, it is our hope that this strategy can be used to map genes whose phenotype depends, at least in part, on non- genetic factors such as exposure to viruses or toxins. In general, linkage disequilibrium will only exist between genes that are physically very close to each other, so we needed to identify types of populations that might show linkage disequilibrium between genes that are relatively loosely linked. Two types of populations that meet this requirement are (1) populations that have a recent bottleneck or founder event in their evolutionary history and (2) populations that have a recent history of racial admixture. The former type of population might be less general or useful on theoretical grounds; for instance, if there is a reduction in overall genetic variability. We have therefore concentrated on the evaluation of mapping genes in racially admixed populations. Our investigations thus far have been designed to identify and evaluate all of the relevant parameters expected to be encountered in a mapping study of this sort. Additionally, our work has focussed on identification and evaluation of the strategies or criteria used for discerning that linkage exists between a pair of genes.

我们的研究集中在通过基因定位的可行性上， 连锁不平衡 连锁不平衡表现在 群体水平，因此具有一定的优势，比定位基因， 系谱分析 特别是，我们希望这一战略能够 用于绘制其表型至少部分取决于非遗传因素的基因， 遗传因素，如接触病毒或毒素。 总的来说， 连锁不平衡只存在于基因之间， 彼此非常接近，所以我们需要确定种群的类型， 这可能表明基因之间的连锁不平衡， 松散的联系。 满足这一要求的两类人群是 (1)最近有瓶颈或创始人事件的人群， （2）有进化史的人群， 种族混杂 前一类人口可能不那么普遍， 在理论上有用;例如，如果 整体遗传变异。 因此，我们把重点放在 在种族混合群体中定位基因的评价。 我们 迄今为止，调查的目的是查明和评价所有 预计在绘制研究中会遇到的相关参数 这种。 此外，我们的工作重点是识别和 评价用于识别这种联系的战略或标准 存在于一对基因之间。