GENETIC, EVOLUTIONARY, AND PHYLOGENETIC ANALYSIS OF HUMAN ALLELES

种群遗传学、分子进化和系统发育重建 是一系列的学科，提供了不同的视角 人类遗传病的一些更有趣的问题， 包括癌症。理论和应用方面的重大进展 这些学科中的一部分现在可以通过精致的细节 对人类和其他正在出现的基因组的理解。研究 该项目的目标主要涉及到发展和 人口统计学、遗传学和系统发育分析的应用。在……里面 具体地说，这些分析模式正被用于支持新基因 从识别到本地化的映射策略 疾病和疾病易感基因的研究 等位基因中的关键功能基序和疾病相关基序 人类主要组织相容性复合体。这些项目是相互关联的， 并且有着共同的目标，那就是推断历史上的联想模式 以及维持或摧毁它们的机制。只有到那时，它才会成为 有可能确定观察到的基因或等位基因关联是否 真正起作用的(例如，与疾病相关的)或仅仅是 历史上的种群遗传或进化过程。

Population genetics, molecular evolution, and phylogenetic reconstruction are a continuum of disciplines that provide different perspectives on some of the more interesting questions of human genetic disease, including cancer. Major advances in both the theory and the application of these disciplines are now possible with the exquisitely detailed understanding of human and other genomes that is emerging. Research objectives of this project primarily concern the development and application of demographic, genetic, and phylogenetic analyses. In particular, these modes of analysis are being used to underpin novel gene mapping strategies that range from the identification and localization of disease and disease susceptibility genes to studies mapping the critical functional and disease-related motifs within alleles of the human major histocompatibility complex. These projects are interrelated, and share the common goal of inferring historical patterns of association and the mechanisms that maintain or destroy them. Only then will it be possible to determine whether observed genic or allelic associations are truly functional (e.g., disease related) or simply a consequence of historic population genetic or evolutionary processes.