GENETIC, EVOLUTIONARY, AND PHYLOGENETIC ANALYSIS OF HUMAN ALLELES
GENETIC, EVOLUTIONARY, AND PHYLOGENETIC ANALYSIS OF HUMAN ALLELES
批准号:
5201542
负责人:
J C STEPHENS
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
中文摘要
种群遗传学、分子进化和系统发育重建
是一系列的学科,提供了不同的视角
人类遗传病的一些更有趣的问题,
包括癌症。理论和应用方面的重大进展
这些学科中的一部分现在可以通过精致的细节
对人类和其他正在出现的基因组的理解。研究
该项目的目标主要涉及到发展和
人口统计学、遗传学和系统发育分析的应用。在……里面
具体地说,这些分析模式正被用于支持新基因
从识别到本地化的映射策略
疾病和疾病易感基因的研究
等位基因中的关键功能基序和疾病相关基序
人类主要组织相容性复合体。这些项目是相互关联的,
并且有着共同的目标,那就是推断历史上的联想模式
以及维持或摧毁它们的机制。只有到那时,它才会成为
有可能确定观察到的基因或等位基因关联是否
真正起作用的(例如,与疾病相关的)或仅仅是
历史上的种群遗传或进化过程。
英文摘要
Population genetics, molecular evolution, and phylogenetic reconstruction
are a continuum of disciplines that provide different perspectives on
some of the more interesting questions of human genetic disease,
including cancer. Major advances in both the theory and the application
of these disciplines are now possible with the exquisitely detailed
understanding of human and other genomes that is emerging. Research
objectives of this project primarily concern the development and
application of demographic, genetic, and phylogenetic analyses. In
particular, these modes of analysis are being used to underpin novel gene
mapping strategies that range from the identification and localization
of disease and disease susceptibility genes to studies mapping the
critical functional and disease-related motifs within alleles of the
human major histocompatibility complex. These projects are interrelated,
and share the common goal of inferring historical patterns of association
and the mechanisms that maintain or destroy them. Only then will it be
possible to determine whether observed genic or allelic associations are
truly functional (e.g., disease related) or simply a consequence of
historic population genetic or evolutionary processes.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
INDICES FOR MONITORING GENOME MAPPING PROGRESS
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批准号:3752728
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项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:J C STEPHENS
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依托单位:
THEORETICAL INVESTIGATIONS OF GENETIC IDENTITY AND DISEQUILIBRIA
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批准号:3774891
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:J C STEPHENS
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依托单位:
INDICES FOR MONITORING GENOME MAPPING PROGRESS
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批准号:3774890
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:J C STEPHENS
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依托单位:
APPROACHES TO GENE MAPPING DEVELOPMENT AND APPLICATIONS
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批准号:6160949
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:J C STEPHENS
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依托单位:
THEORETICAL INVESTIGATIONS OF GENETIC IDENTITY AND DISEQUILIBRIA
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批准号:3838464
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:J C STEPHENS
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依托单位:
COMPARATIVE GENOME MAPPING INDICES
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批准号:3838463
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:J C STEPHENS
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依托单位:
GENETIC, EVOLUTIONARY, AND PHYLOGENETIC ANALYSIS OF HUMAN ALLELES
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批准号:6100848
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:J C STEPHENS
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依托单位:
GENETIC, EVOLUTIONARY, AND PHYLOGENETIC ANALYSIS OF HUMAN ALLELES
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批准号:2463671
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:J C STEPHENS
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依托单位:
INVESTIGATIONS OF GENETIC DISEQUILIBRIA AS GENE MAPPING STRATEGIES
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批准号:3752729
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:J C STEPHENS
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依托单位:
APPROACHES TO GENE MAPPING DEVELOPMENT AND APPLICATIONS
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批准号:5201543
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:J C STEPHENS
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依托单位:
ESTIMATION OF HETEROZYGOSITY FOR SINGLE PROBE, MULTIL. DNA FINGER.
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批准号:3853575
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项目类别:
-
资助金额:$0.0万
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财政年份:--
-
负责人:J C STEPHENS
-
依托单位:
GENETIC, EVOLUTIONARY, AND PHYLOGENETIC ANALYSIS OF HUMAN ALLELES
-
批准号:6160948
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:J C STEPHENS
-
依托单位:
APPROACHES TO GENE MAPPING DEVELOPMENT AND APPLICATIONS
-
批准号:2463672
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:J C STEPHENS
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依托单位:
GENETIC, EVOLUTIONARY, AND PHYLOGENETIC ANALYSIS OF HUMAN ALLELES AND HAPLOTYPES
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批准号:6289141
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项目类别:
-
资助金额:$0.0万
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财政年份:--
-
负责人:J C STEPHENS
-
依托单位:
APPROACHES TO GENE MAPPING DEVELOPMENT AND APPLICATIONS
-
批准号:6100849
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:J C STEPHENS
-
依托单位:
APPROACHES TO GENE MAPPING DEVELOPMENT AND APPLICATIONS
-
批准号:6289142
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项目类别:
-
资助金额:$0.0万
-
财政年份:--
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负责人:J C STEPHENS
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依托单位:
PROGRESS TOWARDS MAPPING THE HUMAN GENOME
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批准号:3853574
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项目类别:
-
资助金额:$0.0万
-
财政年份:--
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负责人:J C STEPHENS
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依托单位:
海外基金