INDICES FOR MONITORING GENOME MAPPING PROGRESS

监测基因组作图进展的指数

• 批准号: 3774890
• 负责人: J C STEPHENS
• 金额: --
• 依托单位: DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3774890
• 关键词: animal population genetics; chromosomes; computer graphics /printing; computer program /software; cytogenetics; cytokine; cytokine receptors; genetic mapping; genetic polymorphism; genome; growth factor; growth factor receptors; human data; human genetic material tag; human population genetics; laboratory mouse; nucleic acid probes; oncogenes; species difference; statistics /biometry; tumor suppressor genes

Statistics and computer programs for monitoring the progress of genome mapping in humans and other species have been developed. One series of statistics is used to estimate the probabilities of synteny in any pair of species for which gene mapping data are available. Specifically, we have estimates for the probability of synteny (1) within each species, (2) of a pair of loci in one species given their synteny on a specific chromosome in the other species, (3) of a pair of loci in one species given their synteny on any chromosome in the other species, and (4) of a pair of loci in either species given synteny in the other species. We have applied these statistics to updated comparative mapping data, including the human versus mouse map, which now includes 670 autosomal loci. Additionally, we have now devised estimates of the variance of our probability estimates. Computer programs for calculating these estimates are being prepared for distribution. Additional programs for summarizing human cytogenetic mapping data and displaying these data graphically have been improved and used for several reports, including the cytogenetic maps (1) of all known human genes; (2) of all loci corresponding to Centre D'Etude du Polymorphisme Humaine (CEPH) probes; and (3) of all oncogenes, tumor suppressors, growth factors, lymphokines, cytokines, receptors, endogenous retroviral elements, and genes related to any of these.

用于监测基因组进展的统计学和计算机程序