COMPARATIVE GENOME MAPPING INDICES

比较基因组作图指数

• 批准号: 3838463
• 负责人: J C STEPHENS
• 金额: --
• 依托单位: DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3838463
• 关键词: Mammalia; Primates; chromosomes; evolution; genetic mapping; genome; human genetic material tag; human population genetics; species difference; statistics /biometry

A series of statistics derived from comparative gene mapping data has been developed to estimate probabilities of synteny (co-occurrence of loci on the same chromosome) in pairwise species comparisons. Currently, the focus is on the following statistical estimates: (1) the within-species synteny for each species, (2) the probability of synteny of a pair of loci in species A given synteny on a specific chromosome in species B (and vice versa), (3) the probability of synteny of a pair of loci in species A given synteny on any chromosome in species B (and vice versa), and (4) the probability of synteny of a pair of loci in one species given synteny in the other species. The definition of these quantities leads to precisely defined probabilities that may be of use in comparative gene mapping studies. For instance, the fourth quantity has been called the "Syntenic Index" and has been used to measure species divergence at the level of chromosomal evolution. Current data sets allow pairwise comparisons to be made among 12 species of primates (122 loci) and among human and 11 other mammalian (nonprimate) species (334 loci).

从比较基因定位数据中得到的一系列统计数据， 开发用于估计同线性的概率（基因座在 相同的染色体）进行成对物种比较。 目前 重点是以下统计估计：（1）种内 每个物种的同线性，（2）一对基因座的同线性概率 在物种A中，在物种B中的特定染色体上给定同线性（反之亦然 反之亦然），（3）物种A中一对基因座的同线性概率 在物种B中的任何染色体上给定同线性（反之亦然），以及（4） 一个物种中一对基因座的同线性概率 其他物种。 这些量的定义精确地导致 可能用于比较基因定位的确定的概率 问题研究 例如，第四个量被称为“同线 指数”，并已被用来衡量物种分歧的水平， 染色体进化 目前的数据集允许成对比较， 在12种灵长类动物（122个位点）和人类以及11种其他动物中进行 哺乳动物（非灵长类）物种（334个位点）。