DETECTION OF DRUGS OF ABUSE IN HUMAN SALIVA

人类唾液中滥用药物的检测

• 批准号: 3774991
• 负责人: E J CONE
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON DRUG ABUSE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3774991
• 关键词: blood chemistry; cocaine; drug abuse; drug detection; evaluation /testing; gas chromatography mass spectrometry; opiate alkaloid; radioimmunoassay; saliva

The presence of drugs of abuse in saliva of human subjects after drug administration was studied to determine the feasibility of drug testing with saliva as the biological specimen. Healthy subjects with a history of chemical substance abuse volunteered for these studies. Informed consent was obtained and all procedures were approved by the hospital Institutional Review Board. Following the administration of cocaine, marijuana or opiates, saliva and blood samples were collected periodically. Behavioral and physiological measures were made concurrently with collection of biological fluids. Samples were analyzed by radioimmunoassay and gas chromatography/mass spectrometry. Significant correlation's of blood levels with saliva levels were found for cocaine and opiates. These studies provide the scientific basis for development of new non- invasive saliva tests for drugs of abuse.

药物滥用后人类受试者唾液中药物的存在 管理进行了研究，以确定药物测试的可行性 用唾液作为生物样本。 有病史的健康受试者 滥用化学物质的人自愿参加这些研究。 知情 获得同意书，所有程序均得到医院批准 机构审查委员会。 服用可卡因后， 收集大麻或鸦片制剂、唾液和血液样本 周期性地。 采取了行为和生理措施 同时收集生物流体。 分析样品 通过放射免疫分析和气相色谱/质谱法。 发现血液水平与唾液水平有显著相关性 可卡因和鸦片 这些研究为开发新的非生物农药提供了科学依据。 滥用药物的侵入性唾液测试