DETECTION OF DRUGS OF ABUSE IN HUMAN SALIVA

人体服药后唾液中是否存在滥用药物 对药物管理进行了研究以确定药物测试的可行性 以唾液为生物标本。有病史的健康受试者 化学物质滥用的人自愿参加这些研究。知情者 得到了医院的同意，所有的手术都得到了医院的批准 院校检讨委员会。在注射了可卡因之后， 采集了大麻或鸦片、唾液和血液样本 定期。进行了行为和生理测量。 同时收集生物体液。对样品进行了分析 采用放射免疫法和气相色谱/质谱法。 血液浓度与唾液浓度之间存在显著的相关性 可卡因和鸦片类药物。 这些研究为新型非金属材料的开发提供了科学依据。 对滥用药物进行侵入性唾液测试。

The presence of drugs of abuse in saliva of human subjects after drug administration was studied to determine the feasibility of drug testing with saliva as the biological specimen. Healthy subjects with a history of chemical substance abuse volunteered for these studies. Informed consent was obtained and all procedures were approved by the hospital Institutional Review Board. Following the administration of cocaine, marijuana or opiates, saliva and blood samples were collected periodically. Behavioral and physiological measures were made concurrently with collection of biological fluids. Samples were analyzed by radioimmunoassay and gas chromatography/mass spectrometry. Significant correlation's of blood levels with saliva levels were found for cocaine and opiates. These studies provide the scientific basis for development of new non- invasive saliva tests for drugs of abuse.