ASSESSMENT OF THE RISK OF PASSIVE INHALATION OF DRUGS OF ABUSE

被动吸入滥用药物的风险评估

• 批准号: 3775066
• 负责人: E J CONE
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON DRUG ABUSE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3775066
• 关键词: controlled environment; crack cocaine; environmental toxicology; human subject; inhalation drug abuse; methamphetamine; passive smoking

When drugs of abuse are smoked, volatile components and pyrolysis material escape into the atmosphere. Depending on the local environment, bystanders may be exposed to the drug by passive inhalation of the contaminated air. Artificial methods have been developed to smoke drugs of abuse in a controlled environment and to measure drug air levels. These methods are then applied to the design of human clinical studies to assess the hazards of environmental exposure to drugs. Initially, free-base cocaine "crack" and methamphetamine "ice" will be evaluated. Unknowing drug exposure could be dangerous to unsuspecting bystanders, particularly to small children. These studies will establish limits of exposure to volatile components of drugs under controlled conditions.

当吸食滥用药物时，挥发性成分和热解 物质逃逸到大气中。根据当地的环境， 旁观者可能会通过被动吸入 被污染的空气。 已经开发出人工方法来吸食滥用药物 受控环境和测量药物空气水平。这些方法是 然后应用于人类临床研究的设计，以评估 环境中暴露于毒品的危害。最初，无碱可卡因 “可卡因”和冰毒“冰”将被评估。 对毫无戒心的旁观者来说，不知情的毒品暴露可能是危险的， 尤其是对年幼的儿童。这些研究将确定以下限制 在受控条件下接触药物的挥发性成分。