AUTOMATED PRODUCTION OF (18F) FLUORODOPA

(18F) 氟多巴的自动化生产

• 批准号: 3789462
• 负责人: S B LEIGHTON
• 金额: --
• 依托单位: NATIONAL CENTER FOR RESEARCH RESOURCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3789462
• 关键词: biomedical automation; chemical synthesis; dihydroxyphenylalanine; fluorine; high performance liquid chromatography; method development; particle accelerators; radiochemistry; radiopharmacology; radiotracer

An automatic system for synthesizing (18F)fluorodopa (and potentially other radiopharmaceuticals) is being developed. It is expected that this system will reduce operator exposure to ionizing radiation, improve product yields, and shorten production cycles. The automatic system is an improvement of an existing manual system that runs in a radioactive hot cell associated with the NIH cyclotron. The starting point of the reaction is (18F)F2 produced by the cyclotron. Steps include column absorbtions and elutions, vacuum evaporation and HPLC. The new system will be able to run unattended under computer control after initial loading of reagent reservoirs.

一种用于合成（18F）氟多巴（和潜在地 其他放射性药物）正在开发中。 预计这一 系统将减少操作员暴露于电离辐射， 产品产量高，缩短生产周期。 自动系统是 对现有手动系统的改进， 与NIH回旋加速器相关的热室。 的起点 反应是由回旋加速器产生的（18 F）F2。 步骤包括列 吸收和洗脱，真空蒸发和HPLC。 新系统 将能够运行无人值守计算机控制后，初始 试剂容器的装载。