COMBINED THERAPY OF HYPERCHOLESTEROLEMIA WITH COLESTIPOL AND FISH OIL

考来酚和鱼油联合治疗高胆固醇血症

• 批准号: 3786500
• 负责人: WILLIAM E. CONNOR
• 金额: --
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3786500
• 关键词: antihypercholesterolemic agent; apolipoproteins; blood lipoprotein metabolism; cholesterol; colestipol; combination chemotherapy; diet therapy; eicosanoids; human subject; human therapy evaluation; hypercholesterolemia; leukocytes; lipid biosynthesis; marine animal oil; metabolism disorder chemotherapy; nutrition related tag; omega 3 fatty acid; steroid biosynthesis

This study examines the effectiveness of combined therapy with colistipol and omega-3 fatty acids, eicosapentanoic and docosahexanoic acids, in the treatment of hypercholesterolemia. Responses are evaluated by measuring lipoprotein and apoprotein levels, whole body cholesterol biosynthesis and lipid synthesis in leukocytes.

本研究探讨了联合治疗的有效性与粘菌素 和ω-3脂肪酸，二十碳五烯酸和二十二碳六烯酸， 高胆固醇血症的治疗。 通过测量来评估响应 脂蛋白和载脂蛋白水平，全身胆固醇生物合成 以及白细胞中的脂质合成。