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REGULATION OF BLOOD PRESSURE AND CHOLESTEROL METABOLISM BY DIETARY FATS

REGULATION OF BLOOD PRESSURE AND CHOLESTEROL METABOLISM BY DIETARY FATS
膳食脂肪对血压和胆固醇代谢的调节
批准号：
3786531
负责人：
DAVID A MCCARRON
金额：
$0.0万
依托单位：
OREGON HEALTH & SCIENCE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3786531
关键词：
antihypertensive agents calcium flux cholesterol diet therapy dietary lipid erythrocyte membrane human subject hypertension lipid metabolism marine animal oil nutrition related tag platelets vegetable oils

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英文摘要
The objective of this proposal is to compare the effect of butterfat, safflower oil, and fish oil on BP regulation in humans. We hypothesize that fish oil will lower BP to the greatest extent, while butterfat and safflower oil will not differ from one another. Ca2+ efflux from RBC membranes is expected to be higher, and platelet [Ca2+]i is expected to be lower in cells harvested from humans during the fish oil-based diet than during either the butterfat or safflower oil phases.
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