CLINICAL NUTRITION RESEARCH UNIT

临床营养研究室

• 批准号: 3102149
• 负责人: DAVID A MCCARRON
• 金额: $ 41.19万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-02-01 至 1994-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3102149
• 关键词: cardiovascular disorder; nutrition

Degenerative disorders of the cardiovascular system result in premature morbidity and mortality in the elderly. Through the five components of the CNRU (core laboratory facilities, pilot/feasibility projects, new investigator training, professional and general educational programs, and nutritional support services) , we will explore the relationship of diet to disorders of the cardiovascular system and degenerative disorders of the elderly that track with cardiovascular disease. Specifically, this CNRU will focus on the impact of dietary intakes of calcium and lipids and their metabolism on the occurrence and/or treatment of hypertension (including alcohol-induced hypertension), hyperlipidemia, toxic nephropathy, cataract formation, and type II diabetes. Utilizing the resources of four established research programs (two dedicated solely to nutrition research) at the Oregon Health Sciences University, we propose a five-year program of scientific investigation and research training. This collaborative plan unites investigators from the departments of Medicine (Nephrology; Endocrinology, Metabolism, and Clinical Nutrition; Cardiology), Ophthalmology, Medical Psychology, Obstetrics and Gynecology, Cell Biology, and Surgery who are committed to clinical and basic science research related to common disorders in the older population. Their particular expertise in calcium and lipid metabolism will serve as the base for a multidisciplinary effort unique in its objectives to explore the relationships among hypertension, hyperlipidemia, cataracts, type II diabetes, and alcohol abuse in the older population. The clinical studies include epidemiologic and intervention studies; the basic investigations will utilize experimental models, organ preparations, and cellular and subcellular techniques. Core facilities in biostatistics and nutrient assessment, hormone and mineral metabolism, lipid metabolism, cell Ca2+, and vascular physiology will serve to facilitate the proposed collaborative pilot projects, the research training, and the investigative programs of the Nutrition Support Service. The administrative core will coordinate these activities as well as the nutrition education of students and health professionals, and will sustain and expand established public information activities reflecting the research focus of this CNRU.

心血管系统退行性疾病导致早产 老年人的发病率和死亡率。通过以下五个组件， CNRU(核心实验室设施、试点/可行性项目、新 调查员培训、专业和一般教育方案，以及 营养支持服务)，我们将探讨饮食与 对心血管系统疾病和退行性疾病的影响 追踪心血管疾病的老年人。具体地说，这 CNRU将重点关注饮食中钙和脂类摄入量的影响以及 它们在高血压发生和/或治疗中的代谢作用 (包括酒精性高血压)、高脂血症、毒性 肾病、白内障形成和II型糖尿病。 利用四个既定研究方案的资源(两个 专门致力于营养研究)在俄勒冈健康科学 大学，我们提出了一项为期五年的科学调查和 研究训练。这一协作计划将来自 医学系(肾脏、内分泌学、新陈代谢和 临床营养学、心脏病学)、眼科学、医学心理学、 产科和妇科学，细胞生物学和外科，致力于 与常见疾病相关的临床和基础科学研究 人口老龄化。他们在钙和脂肪方面的特殊专业知识 新陈代谢将作为一项独特的多学科努力的基础 其目的是探讨高血压与高血压、 高脂血症、白内障、II型糖尿病和酗酒 人口老龄化。临床研究包括流行病学和 干预研究；基础调查将利用实验 模型、器官制备以及细胞和亚细胞技术。 生物统计和营养评估、激素和 矿物质代谢、脂肪代谢、细胞钙离子和血管生理学 将有助于促进拟议的协作试验计划， 研究培训和营养支持的调查计划 服务。行政核心也将协调这些活动。 作为对学生和卫生专业人员的营养教育，并将 维持和扩大既定的新闻活动，反映 本课题的研究重点是CNRU。