CALCIUM INTAKE, METABOLISM & GESTATIONAL BLOOD PRESSURE

钙摄入量、新陈代谢

• 批准号: 3357048
• 负责人: DAVID A MCCARRON
• 金额: $ 13.98万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-09-30 至 1991-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3357048
• 关键词: 1,25 dihydroxycholecalciferol; blood chemistry; blood pressure; calcitonin; calcium metabolism; creatinine; cyclic AMP; dietary calcium; gestational age; hormone regulation /control mechanism; human pregnant subject; human subject; infant human (0-1 year); lactation; longitudinal human study; magnesium; metal metabolism; mother /embryo /fetus nutrition; nutrition related tag; parathyroid hormones; perinatal; phosphorus metabolism; potassium; pregnancy; pregnancy toxemia /hypertension; radioimmunoassay; sodium; urinalysis

The importance of maintaining dietary calcium intake and normal calcium metabolism for optimal regulation of arterial pressure in humans and experimental models has been demonstrated by us and other investigators. Recent reports have suggested that low dietary calcium intake and disturbances in maternal calcium metabolism may be associated with an increases in blood pressure during late gestation. These factors may be associated with an increase in the risk of developing pregnancy-induced hypertension. To explore this hypothesis, during year 1 of this proposal dietary calcium intake and biochemical markers of calcium metabolism will be assessed and compared during the 3rd trimester in 40 women with pregnancy-induced hypertension and 40 normotensive matched controls to determine if significant differences exist in dietary calcium intake and metabolic indices of calcium between these two groups. From 4-6 weeks postpartum, blood pressure, calcium intake, and the same biochemical markers will be reassessed in both lactating and non-lactating women. During years 2-5, we will prospectively assess blood pressure, nutrient intake, and markers of calcium metabolism in a group of 300 clinically normal women from 24 to 36 weeks of pregnancy. Nutrient intake, including dietary calcium, will be assessed during gestation weeks 24, 28, 32, 36, and the postpartum period using 3- day food records and 24-hour dietary recalls. Concomitantly, serum measures of calcium metabolism will be assessed including serum total and ionized calcium, parathyroid hormone, calcitonin, and 1,25(OH)2 vitamin D3 concentrations and serum magnesium, phosphorus, sodium, and potassium concentrations. During weeks 24 and 32, urinary excretion of sodium, calcium, magnesium, potassium, phosphorus, cAMP, and creatinine will be measured. Blood pressure will be measured at every prenatal visit and postpartum. Measures of infant growth and blood pressure will be assessed at 1, 6, and 12 months of age to determine if maternal dietary calcium intake, calcium metabolism, and/or maternal gestational blood pressure exert long-term influences on infant development and blood pressure. The results of this study will provide further insights into the possible role of dietary calcium intake and maternal calcium homeostasis in the regulation of blood pressure in normal pregnancy and pregnancy complicated by hypertension. These observations should provide data to construct testable hypotheses for further research into the putative mechanisms of calcium's influence in pregnancy-induced hypertension.

维持膳食钙摄入量和正常 钙代谢对动脉压的最佳调节 人类和实验模型已经被我们证明， 其他调查员。 最近的报告显示， 膳食钙摄入和母体钙紊乱 新陈代谢可能与血压升高有关 在怀孕后期 这些因素可能与 增加患妊娠高血压的风险。 为了探索这一假设，在本建议饮食的第一年， 钙摄入量与钙代谢生化指标 将在40个月的第三个三个月进行评估和比较 患有妊娠高血压的女性和40名血压正常的女性 匹配的对照，以确定是否存在显著差异， 膳食钙摄入量和钙代谢指标之间的关系 这两个群体。 产后4-6周，血压， 钙的摄入量，同样的生化指标将 在哺乳期和非哺乳期妇女中重新评估。 期间 第2-5年，我们将前瞻性评估血压、营养 摄入量和钙代谢的标志物， 怀孕24至36周的临床正常妇女。 营养素摄入量，包括膳食钙，将在 妊娠第24、28、32、36周和产后期使用3- 每日食物记录和24小时饮食回顾。 同时， 将评估钙代谢的血清指标，包括 血清总钙和离子钙，甲状旁腺激素，降钙素， 和1，25（OH）2维生素D3浓度和血清镁， 磷钠钾浓度 周期间 24和32，尿中钠，钙，镁， 将测量钾、磷、cAMP和肌酐。 每次产前访视时测量血压， 产后 婴儿生长和血压的测量将 在1个月、6个月和12个月大时进行评估， 膳食钙摄入量、钙代谢和/或母体 妊娠期血压对婴儿的长期影响 发展和血压。 这项研究的结果将 提供进一步的见解，可能的作用，膳食钙 摄入量和母体钙稳态的调节 正常妊娠和妊娠合并高血压 高血压 这些观察结果应提供数据， 可检验的假设，以进一步研究假定的 钙对妊娠的影响机制 高血压