CLINICAL NUTRITION RESEARCH UNIT

临床营养研究室

• 批准号: 3102151
• 负责人: DAVID A MCCARRON
• 金额: $ 54.5万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-02-01 至 1994-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3102151
• 关键词: cardiovascular disorder; nutrition; nutrition related tag

Degenerative disorders of the cardiovascular system result in premature morbidity and mortality in the elderly. Through the five components of the CNRU (core laboratory facilities, pilot/feasibility projects, new investigator training, professional and general educational programs, and nutritional support services) , we will explore the relationship of diet to disorders of the cardiovascular system and degenerative disorders of the elderly that track with cardiovascular disease. Specifically, this CNRU will focus on the impact of dietary intakes of calcium and lipids and their metabolism on the occurrence and/or treatment of hypertension (including alcohol-induced hypertension), hyperlipidemia, toxic nephropathy, cataract formation, and type II diabetes. Utilizing the resources of four established research programs (two dedicated solely to nutrition research) at the Oregon Health Sciences University, we propose a five-year program of scientific investigation and research training. This collaborative plan unites investigators from the departments of Medicine (Nephrology; Endocrinology, Metabolism, and Clinical Nutrition; Cardiology), Ophthalmology, Medical Psychology, Obstetrics and Gynecology, Cell Biology, and Surgery who are committed to clinical and basic science research related to common disorders in the older population. Their particular expertise in calcium and lipid metabolism will serve as the base for a multidisciplinary effort unique in its objectives to explore the relationships among hypertension, hyperlipidemia, cataracts, type II diabetes, and alcohol abuse in the older population. The clinical studies include epidemiologic and intervention studies; the basic investigations will utilize experimental models, organ preparations, and cellular and subcellular techniques. Core facilities in biostatistics and nutrient assessment, hormone and mineral metabolism, lipid metabolism, cell Ca2+, and vascular physiology will serve to facilitate the proposed collaborative pilot projects, the research training, and the investigative programs of the Nutrition Support Service. The administrative core will coordinate these activities as well as the nutrition education of students and health professionals, and will sustain and expand established public information activities reflecting the research focus of this CNRU.

心血管系统的退行性疾病导致过早 老年人的发病率和死亡率。通过五个组成部分， CNRU（核心实验室设施、试点/可行性项目、新的 研究者培训、专业和一般教育计划，以及 营养支持服务），我们将探讨饮食 心血管系统疾病和退行性疾病， 患有心血管疾病的老年人。具体地说，这 CNRU将重点关注膳食中钙和脂质摄入量的影响， 它们的代谢对高血压的发生和/或治疗的影响 （包括酒精性高血压）、高脂血症、毒性 肾病、白内障形成和II型糖尿病。 利用四个既定研究计划的资源（两个 专门致力于营养研究）在俄勒冈州健康科学 大学，我们提出了一个科学调查的五年计划， 研究训练。这项合作计划将来自 内科（肾脏科、内分泌科、代谢科和 临床营养学;心脏病学），眼科学，医学心理学， 妇产科，细胞生物学和外科谁致力于 临床和基础科学研究有关的常见疾病， 老年人口。他们在钙和脂质方面的专长 代谢将作为一个独特的多学科努力的基础， 其目的是探讨高血压， 高脂血症、白内障、II型糖尿病和酗酒 老年人口。临床研究包括流行病学和 干预研究;基础研究将利用实验 模型、器官制备以及细胞和亚细胞技术。 生物统计学和营养评估、激素和 矿物质代谢、脂质代谢、细胞Ca 2+和血管生理 将有助于促进拟议的合作试点项目， 研究培训和营养支持调查方案 的服务.行政核心也将协调这些活动 作为学生和卫生专业人员的营养教育， 维持和扩大既定新闻活动， 这是CNRU的研究重点。