CALCIUM INTAKE, METABOLISM & GESTATIONAL BLOOD PRESSURE

钙摄入量、新陈代谢

• 批准号: 3357047
• 负责人: DAVID A MCCARRON
• 金额: $ 9.38万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-09-30 至 1991-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3357047
• 关键词: 1,25 dihydroxycholecalciferol; blood chemistry; blood pressure; calcitonin; calcium metabolism; creatinine; cyclic AMP; dietary calcium; gestational age; hormone regulation /control mechanism; human subject; infant human (0-1 year); lactation; longitudinal human study; magnesium; metal metabolism; mother /embryo /fetus nutrition; nutrition related tag; parathyroid hormones; perinatal; phosphorus metabolism; potassium; pregnancy; pregnancy toxemia /hypertension; radioimmunoassay; sodium; urinalysis

The importance of maintaining dietary calcium intake and normal calcium metabolism for optimal regulation of arterial pressure in humans and experimental models has been demonstrated by us and other investigators. Recent reports have suggested that low dietary calcium intake and disturbances in maternal calcium metabolism may be associated with an increases in blood pressure during late gestation. These factors may be associated with an increase in the risk of developing pregnancy-induced hypertension. To explore this hypothesis, during year 1 of this proposal dietary calcium intake and biochemical markers of calcium metabolism will be assessed and compared during the 3rd trimester in 40 women with pregnancy-induced hypertension and 40 normotensive matched controls to determine if significant differences exist in dietary calcium intake and metabolic indices of calcium between these two groups. From 4-6 weeks postpartum, blood pressure, calcium intake, and the same biochemical markers will be reassessed in both lactating and non-lactating women. During years 2-5, we will prospectively assess blood pressure, nutrient intake, and markers of calcium metabolism in a group of 300 clinically normal women from 24 to 36 weeks of pregnancy. Nutrient intake, including dietary calcium, will be assessed during gestation weeks 24, 28, 32, 36, and the postpartum period using 3- day food records and 24-hour dietary recalls. Concomitantly, serum measures of calcium metabolism will be assessed including serum total and ionized calcium, parathyroid hormone, calcitonin, and 1,25(OH)2 vitamin D3 concentrations and serum magnesium, phosphorus, sodium, and potassium concentrations. During weeks 24 and 32, urinary excretion of sodium, calcium, magnesium, potassium, phosphorus, cAMP, and creatinine will be measured. Blood pressure will be measured at every prenatal visit and postpartum. Measures of infant growth and blood pressure will be assessed at 1, 6, and 12 months of age to determine if maternal dietary calcium intake, calcium metabolism, and/or maternal gestational blood pressure exert long-term influences on infant development and blood pressure. The results of this study will provide further insights into the possible role of dietary calcium intake and maternal calcium homeostasis in the regulation of blood pressure in normal pregnancy and pregnancy complicated by hypertension. These observations should provide data to construct testable hypotheses for further research into the putative mechanisms of calcium's influence in pregnancy-induced hypertension.

保持膳食钙摄入量和正常的重要性 钙代谢对动脉压的最佳调节作用 人类和实验模型已经被我们和 其他调查人员。最近的报告表明，低 膳食钙摄入量与母体钙代谢紊乱 新陈代谢可能与血压升高有关。 在妊娠晚期。这些因素可能与 患妊娠高血压综合征的风险增加。 为了探索这一假设，在本提案的第一年， 钙摄入量与钙代谢生化标志物 将在第40个月的第三个月进行评估和比较 妊娠高血压综合征患者和40例血压正常的女性 配对对照以确定是否存在显著差异 膳食钙摄入量与钙代谢指标之间的关系 这两组人。产后4-6周，血压， 钙的摄入量，以及相同的生化标记物 在哺乳期和非哺乳期妇女中进行了重新评估。在.期间 2-5年，我们将前瞻性地评估血压、营养 300名受试者的摄入量和钙代谢指标 临床正常的怀孕24至36周的妇女。 营养摄入量，包括膳食钙，将在#年期间进行评估。 妊娠24周、28周、32周、36周和产后使用3- 日常食物记录和24小时饮食召回。伴随而来的是， 将评估血清钙代谢指标，包括 血清总钙和离子钙，甲状旁腺激素，降钙素， 和1，25(OH)2维生素D3浓度和血清镁， 磷、钠和钾的浓度。在几周内 24和32，尿钠，钙，镁的排泄量， 将测量钾、磷、cAMP和肌酐。 每次产前检查时都要测量血压， 产后。衡量婴儿生长发育和血压的指标将是 在1、6和12个月大时进行评估，以确定母亲是否 膳食钙摄入量、钙代谢和/或母体 妊娠期血压对婴儿的长期影响 发育和血压。这项研究的结果将 对饮食中钙的可能作用提供进一步的见解 摄入量与母体钙稳态调节 正常妊娠和妊娠合并高血压综合征患者的血压 高血压。这些观察应该提供数据来构建 关于推定的进一步研究的可检验假设 钙在引产中的作用机制 高血压。