MULTIPURPOSE ARTHRITIS & MUSCULOSKELETAL DISEASES CENTER

多用途关节炎

• 批准号: 3108294
• 负责人: DENNIS CARSON
• 金额: $ 88.55万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-08-01 至 1996-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3108294
• 关键词: arthritis; human subject; musculoskeletal disorder

This application requests continued support for the Multipurpose Arthritis Center (MAC) in San Diego, California. The collaborating investigators in the Center were previously based at the Scripps Clinic and Research Foundation and at San Diego State University, under the directorship of Dr. Eng M. Tan. Dr. Tan has now transferred the directorship of the Center to Dr. Dennis A. Carson, the director of the Research Component. Since Dr. Carson, and Dr. Robert Kaplan, the director of the Health Services and Education Component, have accepted faculty appointments at the University of California, San Diego (UCSD), the MAC will now be based at this site. The new Center will have greatly expanded facilities, and will include the participation of the Rheumatology Division at the UCSD School of Medicine, the Department of Mathematics and Biostatistics, and the Department of Community and Family Medicine. The MAC is divided into three parts: (1) the Cores; (2) the Research Component; and (3) the Health Services and Education Component. The Cores provide services necessary for the proper functioning of the Research and Health Services and Education components of the Center, and in addition foster interactions among the participating faculty. They consist of (1) an Executive Committee that will be responsible for the scientific direction of the center, (2) an Administrative Core that will plan, develop, and coordinate the ongoing activities of the center, (3) a Clinical core that will recruit and evaluate patients, and that will obtain clinical samples for individual investigators, (4) a Molecular Biology Core that will serve as a shared resource for oligonucleotide synthesis, vector preparation, and training in basic molecular biology techniques, and (5) a Biostatistics Core that will assist in the design, analysis, and evaluation of experimental protocols. The Research Component contains six separate projects: (1) a biochemical and immunologic analysis of the effects of a new anti-monocyte/macrophage agent (2-chlorodeoxyadenosine) in patients with rheumatoid arthritis, (2) a functional and molecular analysis of the autoepitopes on the SS-B/La autoantigen, (3) an analysis of cytokine expression in the synovial tissues from patients with rheumatoid arthritis, using in situ hybridization, (4) a detailed evaluation of a new animal model of systemic autoimmunity induced by mercuric chloride, (5) a dissection of the mechanism by which the HLA Dw4 antigen influences the immune response to the Epstein-Barr virus, and (6) a molecular analysis of the relationship between anti- carbohydrate antibodies and autoantibodies in humans. The Health Services and Education Component contains four separate projects: (1) an investigation of prospective predictors of musculoskeletal problems in a large middle-class retirement community in the San Diego area, (2) an analysis of the impact of musculoskeletal problems on health policy, (3) a trial of the benefits of behavioral interventions for patients with the fibrositis syndrome, and (4) a study of the relationship between learned helplessness and response to methotrexate in patients with rheumatoid arthritis. The new MAC includes individuals with experience and expertise in basic research, health services research, and medical education. Through the auspices of the Center, these individuals will interact to foster arthritis research, training, and education in the growing San Diego community.

此应用程序要求继续支持多用途关节炎 位于加利福尼亚州圣地亚哥的媒体中心(MAC)。合作的调查人员在 该中心以前设在斯克里普斯诊所和研究中心 基金会和圣地亚哥州立大学，由Dr。 陈英美。陈博士现已将该中心的董事职位调至 丹尼斯·A·卡森博士，研究部门主任。自从Dr。 卡森和罗伯特·卡普兰博士，卫生服务和 教育部分，已接受大学的教职员工任命 加州大学圣地亚哥分校(UCSD)的MAC现在将总部设在这个网站。 新中心的设施将大大扩展，并将包括 加州大学圣迭戈分校医学院风湿科的参与， 数学系和生物统计学系 社区和家庭医学。MAC分为三个部分：(1) 核心；(2)研究部分；以及(3)卫生服务和 教育部分。 核心提供正常运行所需的服务 该中心的研究和卫生服务和教育部分，以及 此外，还促进了参与其中的教职员工之间的互动。它们包括 (1)将负责科学研究的执行委员会 中心的方向，(2)将规划的行政核心， 发展和协调中心正在进行的活动，(3)a 临床核心，将招募和评估患者，并将获得 个体研究人员的临床样本，(4)分子生物学核心 这将作为寡核苷酸合成的共享资源，载体 基础分子生物学技术的准备和培训，以及(5)a 生物统计学核心，将协助设计、分析和评估 实验方案。 研究部分包含六个独立的项目：(1)生物化学 一种新的抗单核/巨噬细胞作用的免疫学分析 2-氯脱氧腺苷在类风湿关节炎患者中的应用 SS-B/La自体表位的功能和分子分析 自身抗原；(3)滑膜组织中细胞因子表达的分析 来自类风湿性关节炎患者的原位杂交，(4) 一种新的系统性自身免疫动物模型的详细评价 氯化汞诱导的，(5)机制的剖析，通过 HLADw4抗原对EB免疫应答的影响 病毒，和(6)分子分析抗病毒之间的关系 人类体内的碳水化合物抗体和自身抗体。 卫生服务和教育部分包含四个独立的 项目：(1)未来预测因素的调查 年一个大型中产阶级退休社区的肌肉骨骼问题 圣地亚哥地区，(2)肌肉骨骼的影响分析 关于卫生政策的问题，(3)行为效益的试验 对纤维炎综合征患者的干预，以及(4)一项关于 获得性无助与甲氨蝶呤疗效的关系 在类风湿性关节炎患者中。 新的MAC包括具有基本知识和专业知识的个人 研究、卫生服务研究和医学教育。通过 在该中心的赞助下，这些人将相互作用，以促进关节炎 在不断增长的圣地亚哥社区进行研究、培训和教育。