Genomic analysis of the novel epigenetic modifier Smchd1 as a tumour suppressor

新型表观遗传修饰剂 Smchd1 作为肿瘤抑制因子的基因组分析

• 批准号: nhmrc : 1045936
• 负责人: A/Pr James Murphy
• 金额: $ 41.28万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/genomic-analysis-novel-tumour-suppressor/111801
• 关键词: Genomic; analysis; novel; epigenetic; modifier

Epigenetic modifications are changes made to our DNA that act like punctuation marks in the genome, to instruct the cell when to turn genes on and when to switch them off. Epigenetic control is critical to range of different biological processes, and also goes awry in cancer. We are specifically interested in the role of one new protein involved in epigentic control and characterising its role as a tumour suppressor.

表观遗传修饰是对我们的DNA所做的改变，就像基因组中的标点符号一样，指示细胞何时开启基因，何时关闭基因。表观遗传控制对一系列不同的生物过程至关重要，在癌症中也会出现问题。我们特别感兴趣的是一种新的蛋白质在表观调控中的作用，以及它作为肿瘤抑制因子的特征。