Mechanistic characterisation of the epigenetic modifier Smchd1
Mechanistic characterisation of the epigenetic modifier Smchd1
批准号:
nhmrc : 1098290
负责人:
A/Pr James Murphy
金额:
$82.41万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2016
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2016-01-01 至 2019-12-31
中文摘要
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英文摘要
FSHD is a progressive muscular dystrophy that currently has no treatment or cure. SMCHD1 is known to play an important role in FSHD, where its usual function in switching genes off is imperfect, contributing to disease. In this project we will determine how SMCHD1 switches genes off and what SMCHD1 looks like at the molecular level, so that we can elucidate how to boost SMCHD1 function for FSHD therapy.
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