Targeting necroptosis signalling to counter stroke-induced brain injury

靶向坏死性凋亡信号对抗中风引起的脑损伤

• 批准号: nhmrc : 1124737
• 负责人: A/Pr James Murphy
• 金额: $ 41.32万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targeting-necroptosis-signalling-brain-injury/947434
• 关键词: Targeting; necroptosis; signalling; counter; stroke

The origins of the brain injury that arises from stroke remain a matter of enormous interest. Our work suggests that a poorly understood form of cell death, termed necroptosis, contributes to injury to the brain following stroke. In addition to developing an advanced understanding of this process, we will use drugs developed at the Walter and Eliza Hall Institute to test whether blocking this process might be a plausible therapeutic strategy in stroke patients.

中风引起的脑损伤的起源仍然是一个非常有趣的问题。我们的工作表明，一种鲜为人知的细胞死亡形式，称为坏死性凋亡，有助于中风后的大脑损伤。除了对这一过程有更深入的了解外，我们还将使用沃尔特和伊丽莎霍尔研究所开发的药物来测试阻断这一过程是否可能是中风患者的一种可行的治疗策略。