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WOODCHUCK VIRUS--MOLECULAR BIOLOGICAL STUDIES

WOODCHUCK VIRUS--MOLECULAR BIOLOGICAL STUDIES
土拨鼠病毒——分子生物学研究
批准号：
3790721
负责人：
R H MILLER
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3790721
关键词：
animal viral hepatitis chronic disease /disorder duck hepatitis B virus gene rearrangement genetic promoter element genetic strain genome liver neoplasms marmots mutant open reading frames virus assembly virus genetics virus replication

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中文摘要
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英文摘要
The woodchuck hepatitis virus (WHV) is taxonomically and serologically related to the hepatitis B virus (HBV). Infection with each of these viruses is associated with acute and chronic hepatitis and hepatic cell carcinoma in their respective hosts and these associations appear to be etiological in nature. Thus, WHV infection of woodchucks provides a relevant and convenient model for understanding HBV infections of humans. The following experiments were performed: (1) detection of WHV mutants in chronically infected woodchucks, (2) mutant WHV genomes in serum were found to resemble rearranged viral integrants in hepatocellular carcinoma, (3) analysis of the X gene promoter, (4) newly identified open reading frames of WHV are not essential for virus replication, (5) mutational analysis of the WHV X gene, and (6) analysis of a WHV mutant with a defective precore gene.
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DETECTION OF HEPATITIS B VIRUS DNA USING THE POLYMERASE CHAIN REACTION
MOLECULAR AND COMPUTER ANALYSIS OF THE HEPATITIS B VIRUS GENOME
MOLECULAR BIOLOGY OF HEPATITIS C VIRUS
MOLECULAR BIOLOGY OF HEPATITIS C VIRUS