MATERNAL IMMUNITY AND ANTIBODY RESPONSSE OF OFFSPRING TO PNEUMOCOCCAL TYPE 19FPS

母源免疫对新生儿抗体应答的影响 研究了肺炎球菌19 F型多糖（PS）的后代。 二-- 来自用23价肺炎球菌免疫的母体的周龄BALB/c小鼠 在妊娠期间接种了额外剂量的相同疫苗， 小鼠肺炎球菌抗血清或两者。 年轻的老鼠产生更高的 19 F PS的抗体滴度高于未 出生后接种疫苗或血清。 此外，所有11至12周龄的猴子，接受额外的 一剂23价疫苗、肺炎球菌免疫球蛋白或两者同时产生 19 F PS的IgG抗体滴度在统计学上高于对照组 不同年龄的人 这些结果表明，在某些情况下， 条件下，例如在临界浓度下使用适当剂量的抗原。 妊娠期或产后发育期，可为婴儿提供 对肺炎球菌PS免疫原的抗体反应增强。

The effect of maternal immunization on the antibody response of the offspring to pneumococcal type 19F polysaccharide (PS) was studied. Two- week-old BALB/c mice from mothers immunized with 23-valent pneumococcal vaccine during gestation were given an additional dose of the same vaccine, mouse pneumococcal antiserum, or both. The young mice produced higher titers of antibodies to the 19F PS than the control group that did not receive vaccine or serum after birth. Furthermore, all 11- to 12-week-old monkeys that received an additional dose of 23-valent vaccine, pneumococcal immunoglobulin, or both produced statistically higher titers of IgG antibody to the 19F PS than did controls of various ages. These results suggest that immunization of mothers under certain conditions, such as with an appropriate dose of antigen at a critical period of gestation or postnatal development, could provide young infants with an enhanced antibody response to pneumococcal PS immunogens.