P-GLYCOPROTEIN EXPRESSION IN NORMAL SECRETORY GESTATIONAL ENDOMETRIUM

正常分泌性妊娠子宫内膜中 P-糖蛋白的表达

• 批准号: 3808589
• 负责人: M MERINO
• 金额: --
• 依托单位: DIVISION OF CANCER BIOLOGY AND DIAGNOSIS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3808589
• 关键词: P glycoprotein; endometrium; female; gene expression; glycoproteins; hormone regulation /control mechanism; human tissue; laboratory mouse; menstrual cycle; multidrug resistance; pregnancy; progesterone; secretion

The multidrug-resistance (MDR) gene product, P-glycoprotein (Pl7O) expressed in tumor cells, has also been localized in the apical regions of secretory epithelial cells of the pregnant mouse endometrium. It has also been shown that progesterone interacts with P170 in gravid mouse endometrium. We will study the expression and localization of P170 in the human endometrium of normal controls and patients undergoing therapeutic D&C to investigate if the expression of P170 correlates with progesterone levels of the luteal phase and pregnancy and if P170 plays a role in sustaining progesterone levels necessary to maintain pregnancy.

多药耐药（MDR）基因产物P-糖蛋白（P17 O） 在肿瘤细胞中表达，也定位于顶端区域 妊娠小鼠子宫内膜的分泌上皮细胞。 它有 孕鼠孕酮与P170相互作用 子宫内膜 我们将研究P170在人肝癌细胞中的表达和定位。 正常对照组和接受子宫内膜异位症治疗的患者的子宫内膜 治疗性D&C，以研究P170的表达是否与 孕酮水平的黄体期和怀孕，如果P170发挥作用， 维持妊娠所需的孕酮水平。