MIXED FORMS OF "TALL CELL VARIANT" OF CAPILLARY CARCINOMA

毛细血管癌“高细胞变体”的混合形式

• 批准号: 3813450
• 负责人: M MERINO
• 金额: --
• 依托单位: DIVISION OF CANCER BIOLOGY AND DIAGNOSIS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3813450
• 关键词: biomarker; immunocytochemistry; neoplasm /cancer immunodiagnosis; thyroid neoplasm

The tall cell variant (TCV) of papillary carcinoma has been associated with an aggressive biological behavior. Histologically, these tumors are characterized by the presence of tall oxyphilic cells with the height twice the size of the width. The immunohistochemical profile of these neoplasms, however, has not been reported. We intend to study 18 cases of TCV and to evaluate several tumor markers by the immunohistochemistry technique to investigate if the antigenic profile of TCV differs from usual papillary cancer and if it causes any prognostic significance.

乳头状癌的高细胞变异（TCV）与 一种攻击性的生物行为。从组织学上看，这些肿瘤是 其特征是存在高度两倍的高嗜氧细胞 宽度的大小。这些肿瘤的免疫组织化学特征， 但尚未见报道。我们打算研究 18 个 TCV 病例并 通过免疫组织化学技术评估多种肿瘤标志物 研究 TCV 的抗原谱是否与普通乳头状病毒不同 癌症以及它是否具有任何预后意义。