CELL BIOLOGY OF LYMPHOID CELLS

淋巴细胞的细胞生物学

• 批准号: 3091416
• 负责人: STANLEY G NATHENSON
• 金额: $ 67.35万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-05-01 至 1992-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3091416
• 关键词: cell biology; immunology; lymphatic tissue; natural killer cells

Six investigators will continue to study the cell and molecular biology of lymphoid cells. Cultured cell lines and somatic mutants derived from them will be used wherever possible. Immunologically important molecules from parental and mutant cells will be characterized structurally and functionally. Amongst the questions being addressed are: the origins and targets of NK cells, the biochemical basis of macrophage functions including anti-bacterial activity, the mechanism of unresponsiveness in leprosy, the nature and role of cross reactive idiotypes of anti-DNA antibodies in lupus, the molecular basis of MHC polymorphism and the structural basis of MHC function in cell-cell interactions and antigen presentation, and the molecular basis of the somatic generation of antibody diversity and gene rearrangement associated with B cell differentiation.

六名研究人员将继续研究细胞和分子生物学， 淋巴样细胞 培养的细胞系及其衍生的体细胞突变体 将尽可能使用。 免疫重要分子， 亲本和突变体细胞将在结构上表征， 功能上。 其中正在解决的问题是：起源和 NK细胞的靶点，巨噬细胞功能的生化基础 包括抗菌活性， 麻风，抗DNA交叉反应独特型的性质和作用 狼疮抗体，MHC多态性的分子基础和 细胞间相互作用中MHC功能结构基础与抗原 呈递，以及抗体体细胞生成的分子基础 与B细胞分化相关的多样性和基因重排。