Atoms-to-Animals: Structural Genomics of Immunity
原子到动物:免疫结构基因组学
基本信息
- 批准号:7982794
- 负责人:
- 金额:$ 117.31万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-09-30 至 2015-06-30
- 项目状态:已结题
- 来源:
- 关键词:Amino Acid SequenceAnimal Disease ModelsAnimalsAutoimmune DiseasesBehaviorBiochemicalBiological AssayBiological ProcessCell surfaceCellsCommitCommunicable DiseasesEvolutionGenerationsHealthHumanImmune TargetingImmune responseImmunityImmunologistIn VitroKnock-in MouseLeadMalignant NeoplasmsNatural ImmunityPropertyProteinsReagentResearch InfrastructureResolutionSeriesShapesSpecificityStructural BiologistStructureStructure-Activity RelationshipTherapeuticWorkadaptive immunitybasehuman diseaseimmune functionin vivoinsightmouse modelmutantnovelpublic health relevancestructural biologystructural genomics
项目摘要
DESCRIPTION (provided by applicant): The Immune Function Network (IFN), a consortium of immunologists, geneticists, computational biochemists, and high throughput structural biologists, is committed to the coordinated structural, in vitro biochemical and in vivo functional analyses of the secreted molecules and ectodomains of cell surface molecules that control adaptive and innate immunity. These molecules are validated targets for immune-based therapies to treat a wide range of autoimmune diseases, infectious diseases and cancers, and are indeed therapeutics in their own right. The IFN, subscribes to a series of underlying principles: 1) target selection supports hypothesis-driven structural biology by identifying unique primary amino acid sequence signatures that predict unique structural features, which are in turn responsible for unique biological function; 2) the high resolution structures of these molecules are exceptionally revealing as they inform on oligomeric state, valency, specificity and general architectural features, all of which are fundamental mechanistic contributors to immune function; 3) these structures can be readily exploited by biochemical and computational
approaches to guide the generation of molecules with specifically altered biochemical and biophysical properties; 4) these "surgically-defined" mutants represent novel reagents that will lead to new mechanistic insights in in vitro cell-based assays and in vivo animal models of disease; 5) the molecules predicted to be most informative will guide the generation of knock-in mouse models to provide in vivo structure-function relationships for innate and adaptive immunity. This "Atoms-to-Animals" approach represents the next step in the evolution of Structural Biology as it maximally leverages structural information and provides a comprehensive and powerful paradigm for the study of normal, pathological, and therapeutic immune responses.
PUBLIC HEALTH RELEVANCE: The proteins that control the immune response are fundamentally important for human health, as they protect against infectious diseases and cancer, and their aberrant behavior is responsible for a wide range of devastating autoimmune diseases. Understanding the shapes and structures of these molecules affords the opportunity to develop novel protein-based therapeutics to treat this entire spectrum of human diseases.
描述(由申请人提供):免疫功能网络(IFN)是一个由免疫学家、遗传学家、计算生物化学家和高通量结构生物学家组成的联盟,致力于对控制适应性免疫和先天免疫的细胞表面分子的分泌分子和外胞域进行协调的结构、体外生化和体内功能分析。这些分子是免疫疗法的有效靶点,可以治疗多种自身免疫性疾病、传染病和癌症,而且它们本身确实是治疗药物。IFN遵循一系列基本原则:1)目标选择支持假设驱动的结构生物学,通过识别独特的初级氨基酸序列特征来预测独特的结构特征,这些特征反过来负责独特的生物学功能;2)这些分子的高分辨率结构特别具有揭示性,因为它们告知低聚态,价态,特异性和一般结构特征,所有这些都是免疫功能的基本机制贡献者;3)这些结构可以很容易地被生化和计算利用
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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STANLEY G NATHENSON其他文献
STANLEY G NATHENSON的其他文献
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{{ truncateString('STANLEY G NATHENSON', 18)}}的其他基金
Atoms-to-Animals: Structural Genomics of Immunity
原子到动物:免疫结构基因组学
- 批准号:
8152238 - 财政年份:2010
- 资助金额:
$ 117.31万 - 项目类别:
Consortia for High-Throughput-Enabled Structural Biology Partnerships (U01)
高通量结构生物学合作联盟 (U01)
- 批准号:
8153580 - 财政年份:2010
- 资助金额:
$ 117.31万 - 项目类别:
Mechanisms of beta2-microglubin in Autoimmune Diabetes
β2-微球蛋白在自身免疫性糖尿病中的作用机制
- 批准号:
7070052 - 财政年份:2003
- 资助金额:
$ 117.31万 - 项目类别:
Mechanisms of beta2-microglobulin in Autoimmune Diabetes
β2-微球蛋白在自身免疫性糖尿病中的作用机制
- 批准号:
6678897 - 财政年份:2003
- 资助金额:
$ 117.31万 - 项目类别:
Mechanisms of beta2-microglubin in Autoimmune Diabetes
β2-微球蛋白在自身免疫性糖尿病中的作用机制
- 批准号:
6798150 - 财政年份:2003
- 资助金额:
$ 117.31万 - 项目类别:
Mechanisms of beta2-microglubin in Autoimmune Diabetes
β2-微球蛋白在自身免疫性糖尿病中的作用机制
- 批准号:
6901079 - 财政年份:2003
- 资助金额:
$ 117.31万 - 项目类别:
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