CELL BIOLOGY OF LYMPHOID CELLS
CELL BIOLOGY OF LYMPHOID CELLS
批准号:
3091414
负责人:
STANLEY G NATHENSON
金额:
$92.1万
依托单位国家:
美国
项目类别:
财政年份:
1987
资助国家:
美国
项目状态:
已结题
起止时间:
1987-05-01 至 1992-04-30
中文摘要
六名研究人员将继续研究人乳头瘤的细胞和分子生物学
淋巴样细胞。培养的细胞系及其衍生的体细胞突变体
将在任何可能的情况下使用。重要的免疫学分子来自
亲本细胞和突变细胞将在结构上和
在功能上。正在解决的问题包括:起源和
巨噬细胞功能的生化基础--NK细胞靶点
包括抗菌活性,无反应性的机制
麻风,抗DNA交叉反应独特型的性质和作用
狼疮中的抗体,MHC基因多态性的分子基础和
MHC在细胞-细胞相互作用和抗原中作用的结构基础
以及抗体体细胞产生的分子基础
多样性和基因重排与B细胞分化相关。
英文摘要
Six investigators will continue to study the cell and molecular biology of
lymphoid cells. Cultured cell lines and somatic mutants derived from them
will be used wherever possible. Immunologically important molecules from
parental and mutant cells will be characterized structurally and
functionally. Amongst the questions being addressed are: the origins and
targets of NK cells, the biochemical basis of macrophage functions
including anti-bacterial activity, the mechanism of unresponsiveness in
leprosy, the nature and role of cross reactive idiotypes of anti-DNA
antibodies in lupus, the molecular basis of MHC polymorphism and the
structural basis of MHC function in cell-cell interactions and antigen
presentation, and the molecular basis of the somatic generation of antibody
diversity and gene rearrangement associated with B cell differentiation.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Atoms-to-Animals: Structural Genomics of Immunity
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批准号:8152238
-
项目类别:
-
资助金额:$109.42万
-
财政年份:2010
-
负责人:STANLEY G NATHENSON
-
依托单位:
Consortia for High-Throughput-Enabled Structural Biology Partnerships (U01)
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批准号:8153580
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项目类别:
-
资助金额:$97.32万
-
财政年份:2010
-
负责人:STANLEY G NATHENSON
-
依托单位:
Atoms-to-Animals: Structural Genomics of Immunity
-
批准号:7982794
-
项目类别:
-
资助金额:$117.31万
-
财政年份:2010
-
负责人:STANLEY G NATHENSON
-
依托单位:
Mechanisms of beta2-microglobulin in Autoimmune Diabetes
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批准号:6678897
-
项目类别:
-
资助金额:$29.81万
-
财政年份:2003
-
负责人:STANLEY G NATHENSON
-
依托单位:
Mechanisms of beta2-microglubin in Autoimmune Diabetes
-
批准号:7070052
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项目类别:
-
资助金额:$31.81万
-
财政年份:2003
-
负责人:STANLEY G NATHENSON
-
依托单位:
Mechanisms of beta2-microglubin in Autoimmune Diabetes
-
批准号:6798150
-
项目类别:
-
资助金额:$30.7万
-
财政年份:2003
-
负责人:STANLEY G NATHENSON
-
依托单位:
Mechanisms of beta2-microglubin in Autoimmune Diabetes
-
批准号:6901079
-
项目类别:
-
资助金额:$31.62万
-
财政年份:2003
-
负责人:STANLEY G NATHENSON
-
依托单位:
CELL BIOLOGY OF LYMPHOID CELLS
-
批准号:3091417
-
项目类别:
-
资助金额:$67.35万
-
财政年份:1987
-
负责人:STANLEY G NATHENSON
-
依托单位:
CELL BIOLOGY OF LYMPHOID CELLS
-
批准号:3091415
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项目类别:
-
资助金额:$70.71万
-
财政年份:1987
-
负责人:STANLEY G NATHENSON
-
依托单位:
CELL BIOLOGY OF LYMPHOID CELLS
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批准号:3091416
-
项目类别:
-
资助金额:$67.35万
-
财政年份:1987
-
负责人:STANLEY G NATHENSON
-
依托单位:
THE BIOLOGY OF THE IMMUNE SYSTEM
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批准号:3091410
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项目类别:
-
资助金额:$91.6万
-
财政年份:1987
-
负责人:STANLEY G NATHENSON
-
依托单位:
IMMUNOLOGY AND IMMUNOONCOLOGY TRAINING PROGRAM
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批准号:3532678
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项目类别:
-
资助金额:$42.29万
-
财政年份:1980
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负责人:STANLEY G NATHENSON
-
依托单位:
IMMUNOLOGY AND IMMUNO-ONCOLOGY
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批准号:3532682
-
项目类别:
-
资助金额:$46.98万
-
财政年份:1980
-
负责人:STANLEY G NATHENSON
-
依托单位:
IMMUNOLOGY AND IMMUNUNOOCOLOGY TRAINING PROGRAM
-
批准号:2084993
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项目类别:
-
资助金额:$39.86万
-
财政年份:1980
-
负责人:STANLEY G NATHENSON
-
依托单位:
IMMUNOLOGY AND IMMUNO-ONCOLOGY
-
批准号:3532683
-
项目类别:
-
资助金额:$38.99万
-
财政年份:1980
-
负责人:STANLEY G NATHENSON
-
依托单位:
IMMUNOLOGY AND IMMUNOONCOLOGY TRAINING PROGRAM
-
批准号:6375501
-
项目类别:
-
资助金额:$51.72万
-
财政年份:1980
-
负责人:STANLEY G NATHENSON
-
依托单位:
Immunology and Immunooncology Training Program
-
批准号:7103583
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项目类别:
-
资助金额:$65.12万
-
财政年份:1980
-
负责人:STANLEY G NATHENSON
-
依托单位:
Immunology and Immunooncology Training Program
-
批准号:7671502
-
项目类别:
-
资助金额:$65.6万
-
财政年份:1980
-
负责人:STANLEY G NATHENSON
-
依托单位:
IMMUNOLOGY AND IMMUNOONCOLOGY TRAINING PROGRAM
-
批准号:2084991
-
项目类别:
-
资助金额:$47.01万
-
财政年份:1980
-
负责人:STANLEY G NATHENSON
-
依托单位:
IMMUNOLOGY AND IMMUNOONCOLOGY TRAINING PROGRAM
-
批准号:3532676
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项目类别:
-
资助金额:$40.98万
-
财政年份:1980
-
负责人:STANLEY G NATHENSON
-
依托单位:
国内基金
海外基金
Cellular & Molecular Immunology
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批准号:30824806
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项目类别:专项基金项目
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资助金额:20.0万元
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批准年份:2008
-
负责人:魏海明
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依托单位: