CELL BIOLOGY OF LYMPHOID CELLS

六名研究人员将继续研究人乳头瘤的细胞和分子生物学 淋巴样细胞。培养的细胞系及其衍生的体细胞突变体 将在任何可能的情况下使用。重要的免疫学分子来自 亲本细胞和突变细胞将在结构上和 在功能上。正在解决的问题包括：起源和 巨噬细胞功能的生化基础--NK细胞靶点 包括抗菌活性，无反应性的机制 麻风，抗DNA交叉反应独特型的性质和作用 狼疮中的抗体，MHC基因多态性的分子基础和 MHC在细胞-细胞相互作用和抗原中作用的结构基础 以及抗体体细胞产生的分子基础 多样性和基因重排与B细胞分化相关。

Six investigators will continue to study the cell and molecular biology of lymphoid cells. Cultured cell lines and somatic mutants derived from them will be used wherever possible. Immunologically important molecules from parental and mutant cells will be characterized structurally and functionally. Amongst the questions being addressed are: the origins and targets of NK cells, the biochemical basis of macrophage functions including anti-bacterial activity, the mechanism of unresponsiveness in leprosy, the nature and role of cross reactive idiotypes of anti-DNA antibodies in lupus, the molecular basis of MHC polymorphism and the structural basis of MHC function in cell-cell interactions and antigen presentation, and the molecular basis of the somatic generation of antibody diversity and gene rearrangement associated with B cell differentiation.