EVALUATION OF FREE THYROXIN TECHNIQUES

内源性甲状腺素结合蛋白对甲状腺功能测定的影响 游离甲状腺素（FT4）的五种不同的方法，在16 在非甲状腺疾病（NTI）患者中研究了不同的测定方法。 所有FT4测定均与部分或全部血清中 三种主要的T4结合蛋白（前白蛋白、白蛋白和TBG）。关于FT4 估计数因方法而异， 使用的特定测定（试剂盒）。两步FT4 RIA的结果最少 与结合蛋白浓度相关。

The effect of endogenous thyroxin-binding proteins on the measurement of free thyroxin (FT4) by five different methodologies represented in 16 different assays was studied in patients with nonthyroidal illness (NTI). All FT4 assays correlated with the serum concentration of some or all of the three major T4-binding proteins (prealbumin, albumin, and TBG). The FT4 estimates varied with methodology and to a lesser extent with the particular assay (kit) used. The results from two-step FT4 RIAs were least associated with binding protein concentrations.