APPLICATION OF RAPID FLOW MICROFLUOROMETRY TO CELL BIOLOGY

快速流动显微荧光测定法在细胞生物学中的应用

• 批准号: 3939231
• 负责人: J R WUNDERLICH
• 金额: --
• 依托单位: DIVISION OF CANCER BIOLOGY AND DIAGNOSIS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3939231
• 关键词: B lymphocyte; T lymphocyte; cell biology; cell cell interaction; cell differentiation; computer system design /evaluation; flow cytometry; gene expression; graft versus host disease; human tissue; immune tolerance /unresponsiveness; immunogenetics; immunologic memory; immunotherapy; interleukin 2; major histocompatibility complex; monoclonal antibody; surface antigens

Using rapid flow microfluorometry (FMF) for analysis and sorting of cells, aspects of the following projects have been supported this year: (1) studies of the cellular basis for graft rejection and development of tolerance, (2) studies of the pathogenesis of graft- vs-host disease, (3) analysis of the relationship between memory T cells and their expression of adhesion molecules, (4) investigation of the immune system localized in the skin, (5) investigation of murine MHC class I molecules controlled by genes in the Qa-2 region of chromosome 17, and (6) development of an automated computer aid for multiparameter data processing.

使用快速流动微量荧光法(FMF)进行分析和分类 在单元中，支持了以下项目的各个方面 今年：(1)移植排斥的细胞学基础研究和 耐受性的发展，(2)移植物发病机制的研究 VS-宿主病，(3)记忆T的关系分析 细胞及其黏附分子的表达，(4)研究 定位于皮肤的免疫系统，(5)调查 Qa-2基因控制的小鼠MHC-I类分子 17号染色体区域，以及(6)一种自动化的 用于多参数数据处理的计算机辅助。