MODE OF ACTION OF A BACTERIAL FUNCTION INVOLVED IN CELL GROWTH CONTROL
MODE OF ACTION OF A BACTERIAL FUNCTION INVOLVED IN CELL GROWTH CONTROL
批准号:
3939319
负责人:
S GOTTESMAN
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
关键词:
DNA repair Escherichia coli bacterial genetics bacterial polysaccharides cell capsule cell growth regulation genetic manipulation genetic mapping genetic regulation genetic transcription genetic translation lac operon molecular biology molecular genetics mucopolysaccharides mutant operon peptidases pleiotropism proteolysis regulatory gene
中文摘要
我们一直在研究蛋白质降解所起的作用
英文摘要
We have been studying the role that protein degradation plays in
regulating cell growth control, through the study of mutants
defective in ATP-dependent protein turnover. E. coli lon mutants
are defective in cell division regulation after DNA damage, and
we have previously demonstrated that this defect is due to
stabilization of the highly unstable cell division inhibitor, SulA.
lon mutants also overproduce capsular polysaccharide; we have
identified an unstable positive regulator of capsule synthesis,
RcsA, which is stabilized in lon mutants. The sequence of the
rcsA gene shows no striking similarities to other lon substrates.
rcsA-lac fusions which we have isolated will allow us to examine
the transcriptional and translational control of this gene. Using
cells devoid of lon activity, we have biochemically identified a
novel two-component, ATP-dependent protease. Using amino acid
sequence data from one of the purified components, plasmids
carrying the gene are being identified. Using genetic screens, we
have also identified and partially mapped a function which is
capable of substituting for lon, and presumably codes for another
protease with potential regulatory functions in E. coli.
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BACTERIAL FUNCTION INVOLVED IN CELL GROWTH CONTROL
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批准号:3752048
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:S GOTTESMAN
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依托单位:
BACTERIAL FUNCTION INVOLVED IN CELL GROWTH CONTROL
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批准号:3774336
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:S GOTTESMAN
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依托单位:
MODE OF ACTION OF A BACTERIAL FUNCTION INVOLVED IN CELL GROWTH CONTROL
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批准号:3916344
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:S GOTTESMAN
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依托单位:
BACTERIAL FUNCTION INVOLVED IN CELL GROWTH CONTROL
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批准号:3808540
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:S GOTTESMAN
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依托单位:
MODE OF ACTION OF A BACTERIAL FUNCTION INVOLVED IN CELL GROWTH CONTROL
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批准号:3813384
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:S GOTTESMAN
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依托单位:
BACTERIAL FUNCTION INVOLVED IN CELL GROWTH CONTROL
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批准号:3796484
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:S GOTTESMAN
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依托单位:
BACTERIAL FUNCTION INVOLVED IN CELL GROWTH CONTROL
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批准号:5200961
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:S GOTTESMAN
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依托单位:
MODE OF ACTION OF A BACTERIAL FUNCTION INVOLVED IN CELL GROWTH CONTROL
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批准号:3963039
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:S GOTTESMAN
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依托单位:
MODE OF ACTION OF A BACTERIAL FUNCTION INVOLVED IN CELL GROWTH CONTROL
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批准号:4691867
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:S GOTTESMAN
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依托单位:
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