MODE OF ACTION OF A BACTERIAL FUNCTION INVOLVED IN CELL GROWTH CONTROL
MODE OF ACTION OF A BACTERIAL FUNCTION INVOLVED IN CELL GROWTH CONTROL
批准号:
4691867
负责人:
S GOTTESMAN
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
中文摘要
我们一直在研究蛋白质降解在调节中的作用
英文摘要
We have been studying the role that protein degradation plays in regulating
cell growth control, through the study of mutants defective in
ATP-dependent protein degradation. E. coli lon mutants are defective in
cell division regulation after DNA damage, and we have previously
demonstrated that this defect is due to stabilization of a highly unstable
cell division inhibitor, the product of the SulA gene. lon mutants also
overproduce capsular polysaccharide, and we have developed a system for the
study of the regulation of the genes necessary for capsule synthesis (cps),
suing cps::lac operon fusions. We have isolated and mapped mutations in
three genes which regulate capsule synthesis (rcsA, rcsB, and rcsC). All
three regulatory genes have been cloned, and the protein products are being
identified. Genetic experiments indicated the existence of a cascade of
regulatory interactions to regulate the transcription from the cps
structural genes; future work will allow the in vitro reonstruction of this
regulatory cascade andidentification of the precise role of lon in this
system. Studies on cells devoid of lon activity demonstrate the existence
of other APT-dependent proteolysis systems in E. coli. We will develop
genetic selections for mutations in these other protease genes, as well as
the biochemical characterization of these activities. In addition, we have
demonstrated the in vitro degradation of a natural Lon substrate, the
lambda N protein. Further studies of this degradation process will allow
an analysis of the characteristics of Lon proteolysis.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
BACTERIAL FUNCTION INVOLVED IN CELL GROWTH CONTROL
-
批准号:3752048
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:S GOTTESMAN
-
依托单位:
BACTERIAL FUNCTION INVOLVED IN CELL GROWTH CONTROL
-
批准号:3774336
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:S GOTTESMAN
-
依托单位:
MODE OF ACTION OF A BACTERIAL FUNCTION INVOLVED IN CELL GROWTH CONTROL
-
批准号:3916344
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:S GOTTESMAN
-
依托单位:
BACTERIAL FUNCTION INVOLVED IN CELL GROWTH CONTROL
-
批准号:3808540
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:S GOTTESMAN
-
依托单位:
MODE OF ACTION OF A BACTERIAL FUNCTION INVOLVED IN CELL GROWTH CONTROL
-
批准号:3813384
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:S GOTTESMAN
-
依托单位:
BACTERIAL FUNCTION INVOLVED IN CELL GROWTH CONTROL
-
批准号:3796484
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:S GOTTESMAN
-
依托单位:
MODE OF ACTION OF A BACTERIAL FUNCTION INVOLVED IN CELL GROWTH CONTROL
-
批准号:3939319
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:S GOTTESMAN
-
依托单位:
BACTERIAL FUNCTION INVOLVED IN CELL GROWTH CONTROL
-
批准号:5200961
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:S GOTTESMAN
-
依托单位:
MODE OF ACTION OF A BACTERIAL FUNCTION INVOLVED IN CELL GROWTH CONTROL
-
批准号:3963039
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:S GOTTESMAN
-
依托单位:
国内基金
海外基金
登录
查看更多内容
asr基因调控酸诱导的Escherichia coli O157:H7形成VBNC状态的机制研究
-
批准号:32302245
-
项目类别:青年科学基金项目
-
资助金额:30.00万元
-
批准年份:2023
-
负责人:潘寒姁
-
依托单位:
小肠中Escherichia coli分泌细菌毒素诱导肠屏障损伤及细菌易位在炎症性肠病中的机制研究
-
批准号:82371775
-
项目类别:面上项目
-
资助金额:46万元
-
批准年份:2023
-
负责人:朱慧媛
-
依托单位:
基于Escherichia coli O157:H7亚致死态细胞探究超高压与原儿茶酸协同杀菌机制
-
批准号:31871817
-
项目类别:面上项目
-
资助金额:60.0万元
-
批准年份:2018
-
负责人:孙爱东
-
依托单位:
肠肝轴:从临床患者分离的肠道致病菌株Escherichia coli NF73-1对非酒精性脂肪性肝病的作用及机制研究
-
批准号:81873549
-
项目类别:面上项目
-
资助金额:57.0万元
-
批准年份:2018
-
负责人:刘玉兰
-
依托单位:
高压二氧化碳诱导Escherichia coli O157:H7形成VBNC状态的分子机制
-
批准号:31571933
-
项目类别:面上项目
-
资助金额:57.0万元
-
批准年份:2015
-
负责人:廖小军
-
依托单位:
超高压诱导牛肉中Escherichia coli O157:H7亚致死损伤及其修复研究
-
批准号:31371861
-
项目类别:面上项目
-
资助金额:15.0万元
-
批准年份:2013
-
负责人:江芸
-
依托单位:
高压二氧化碳诱导Escherichia coli O157:H7形成VBNC状态的机制
-
批准号:31371845
-
项目类别:面上项目
-
资助金额:15.0万元
-
批准年份:2013
-
负责人:廖小军
-
依托单位:
高密度二氧化碳致死Escherichia coli的相关蛋白质确证及其结构变化研究
-
批准号:31171774
-
项目类别:面上项目
-
资助金额:66.0万元
-
批准年份:2011
-
负责人:张德权
-
依托单位: