参与细胞生长控制的细菌功能-猫眼课题宝

参与细胞生长控制的细菌功能

批准号：

3796484

负责人：

S GOTTESMAN

金额：

$0.0万

依托单位：

DIVISION OF CANCER BIOLOGY AND DIAGNOSIS

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

未结题

起止时间：

至

来源：

https://reporter.nih.gov/project-details/3796484

关键词：

bacterial capsules bacterial genetics bacterial polysaccharides carbohydrate biosynthesis cell cycle cell growth regulation endopeptidases enzyme induction /repression enzyme mechanism enzyme substrate gene expression molecular chaperones phosphorylation protein biosynthesis protein degradation regulatory gene transcription factor

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中文摘要

翻译

我们一直在研究蛋白质降解在调节中的作用

英文摘要

We have been studying the role that protein degradation plays in regulating gene expression and have continued with studies on the linkages between chromosome synthesis and partition of chromosomes during cell division. As part of continuing studies on the regulation of capsular polysaccharide synthesis by the unstable regulator RcsA, we have found that a downstream transacting regulator of rcsA synthesis encodes RNAs which apparently mediate the regulatory effect. Mutations in both the regulator and target will allow further characterization of the mode of regulation. Mutations in the putative phosphorylation site of RcsB support a role for phosphorylation in capsule regulation. We are investigating the role of the heat shock chaperone proteins in degradation of substrates of the Lon ATP-dependent protease and initiating studies on the recognition specificity of Lon. Studies on the role and regulation of the Clp energy- dependent protease have concentrated on developing strains for the tight regulation of Clp synthesis, and investigating the function of a newly discovered alternate regulatory subunit, ClpX.

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