Deciphering the transcriptional program that instructs lymphatic endothelial cell fate.

破译指导淋巴内皮细胞命运的转录程序。

• 批准号: nhmrc : GNT1107643
• 负责人: A/Pr Natasha Harvey
• 金额: $ 54.2万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/deciphering-transcriptional-program-cell-fate/1346593
• 关键词: Deciphering; transcriptional; program; instructs; lymphatic

Lymphatic vessels are essential to maintain fluid balance in most tissues of the human body. Further the lymphatic vasculature plays a central role during cancer and contributes to tumour metastasis. Despite this integral function in health and disease little is known about the molecular programs that coordinate gene expression to build a functional vasculature. This research project will address this gap in our knowledge and will open up new therapeutic avenues for lymphatic vascular disorders

淋巴管对维持人体大多数组织的体液平衡至关重要。此外，淋巴血管系统在癌症过程中起着核心作用，并有助于肿瘤转移。尽管血管在健康和疾病中起着不可或缺的作用，但人们对协调基因表达以建立功能性血管系统的分子程序知之甚少。该研究项目将解决我们知识上的这一空白，并将为淋巴血管疾病开辟新的治疗途径