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Defining the role of a novel transcriptional enhancer element in regulation of Prox1 expression and endothelial cell identity.

Defining the role of a novel transcriptional enhancer element in regulation of Prox1 expression and endothelial cell identity.
定义新型转录增强子元件在 Prox1 表达和内皮细胞身份调节中的作用。
批准号:
nhmrc : GNT1146706
负责人:
A/Pr Natasha Harvey
金额:
$69.71万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2018
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2018-01-01 至 --

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中文摘要
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英文摘要
The precise spatial and temporal control of gene expression is regulated by non-coding regions of the genome termed enhancers. Enhancers are crucial to program cell identity and have established roles in development and disease. We have identified a novel enhancer that we hypothesise controls the identity of valve endothelial cells by regulating expression of a master programmer of lymphatic endothelial cell identity, PROX1. Here we will investigate the role of this enhancer during development.
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Trafficking mechanisms governing receptor availability for signalling
  • 批准号:
    nhmrc : 1146087
  • 项目类别:
    Project Grants
  • 资助金额:
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  • 财政年份:
    2018
  • 负责人:
    A/Pr Natasha Harvey
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Understanding how GATA2 controls lymphatic vessel valve development
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  • 项目类别:
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  • 财政年份:
    2018
  • 负责人:
    A/Pr Natasha Harvey
  • 依托单位:
Defining the role of a novel transcriptional enhancer element in regulation of Prox1 expression and endothelial cell identity.
  • 批准号:
    nhmrc : 1146706
  • 项目类别:
    Project Grants
  • 资助金额:
    $47.14万
  • 财政年份:
    2018
  • 负责人:
    A/Pr Natasha Harvey
  • 依托单位:
Understanding how GATA2 controls lymphatic vessel valve development
  • 批准号:
    nhmrc : 1146800
  • 项目类别:
    Project Grants
  • 资助金额:
    $46.54万
  • 财政年份:
    2018
  • 负责人:
    A/Pr Natasha Harvey
  • 依托单位:
国内基金
海外基金
PfAP2-R介导的PfCRT转录调控在恶性疟原虫对喹啉类药物抗性中的作用及机制研究
Sestrin2抑制内质网应激对早产儿视网膜病变的调控作用及其机制研究
  • 批准号:
    82371070
  • 项目类别:
    面上项目
  • 资助金额:
    49.00万元
  • 批准年份:
    2023
  • 负责人:
    赵培泉
  • 依托单位: