Trafficking mechanisms governing receptor availability for signalling

控制信号受体可用性的贩运机制

• 批准号: nhmrc : GNT1146087
• 负责人: A/Pr Natasha Harvey
• 金额: $ 52.7万
• 依托单位: University of South Australia
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/trafficking-mechanisms-governing-availability-signalling/1348739
• 关键词: Trafficking; mechanisms; governing; receptor; availability

Receptors on the cell surface allow cells to respond to their environment. We have recently discovered a new pathway for controlling the amount of receptors displayed on the cell surface, errors within which will lead to defects in development and diseases like cancer. We are studying how this new pathway controls the balance between how much receptors are destroyed after being activated and how much are recycled back for re-use.

细胞表面的受体允许细胞对环境做出反应。我们最近发现了一种控制细胞表面受体数量的新途径，其中的错误将导致发育缺陷和癌症等疾病。我们正在研究这种新的途径如何控制受体在被激活后被破坏的数量和被回收再利用的数量之间的平衡。