Defining the role of a novel transcriptional enhancer element in regulation of Prox1 expression and endothelial cell identity.

定义新型转录增强子元件在 Prox1 表达和内皮细胞身份调节中的作用。

• 批准号: nhmrc : 1146706
• 负责人: A/Pr Natasha Harvey
• 金额: $ 47.14万
• 依托单位: University of South Australia
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/defining-role-novel-cell-identity/1320718
• 关键词: Defining; role; novel; transcriptional; enhancer

The precise spatial and temporal control of gene expression is regulated by non-coding regions of the genome termed enhancers. Enhancers are crucial to program cell identity and have established roles in development and disease. We have identified a novel enhancer that we hypothesise controls the identity of valve endothelial cells by regulating expression of a master programmer of lymphatic endothelial cell identity, PROX1. Here we will investigate the role of this enhancer during development.

基因表达的精确空间和时间控制由基因组的非编码区（称为增强子）调节。增强子对于编程细胞身份至关重要，并在发育和疾病中发挥作用。我们已经确定了一种新的增强子，我们假设控制的身份瓣膜内皮细胞通过调节淋巴管内皮细胞的身份，PROX1的主程序的表达。在这里，我们将研究这种增强剂在发育过程中的作用。