Defining the role of a novel transcriptional enhancer element in regulation of Prox1 expression and endothelial cell identity.
Defining the role of a novel transcriptional enhancer element in regulation of Prox1 expression and endothelial cell identity.
批准号:
nhmrc : 1146706
负责人:
A/Pr Natasha Harvey
金额:
$47.14万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2018
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2018-01-01 至 2020-12-31
中文摘要
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英文摘要
The precise spatial and temporal control of gene expression is regulated by non-coding regions of the genome termed enhancers. Enhancers are crucial to program cell identity and have established roles in development and disease. We have identified a novel enhancer that we hypothesise controls the identity of valve endothelial cells by regulating expression of a master programmer of lymphatic endothelial cell identity, PROX1. Here we will investigate the role of this enhancer during development.
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会议论文
Trafficking mechanisms governing receptor availability for signalling
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批准号:nhmrc : 1146087
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项目类别:Project Grants
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资助金额:$35.63万
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财政年份:2018
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负责人:A/Pr Natasha Harvey
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依托单位:
Understanding how GATA2 controls lymphatic vessel valve development
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批准号:nhmrc : GNT1146800
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项目类别:Project Grants
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资助金额:$68.83万
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财政年份:2018
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负责人:A/Pr Natasha Harvey
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依托单位:
Defining the role of a novel transcriptional enhancer element in regulation of Prox1 expression and endothelial cell identity.
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批准号:nhmrc : GNT1146706
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项目类别:Project Grants
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资助金额:$69.71万
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财政年份:2018
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负责人:A/Pr Natasha Harvey
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依托单位:
Understanding how GATA2 controls lymphatic vessel valve development
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批准号:nhmrc : 1146800
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项目类别:Project Grants
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资助金额:$46.54万
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财政年份:2018
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负责人:A/Pr Natasha Harvey
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依托单位:
Trafficking mechanisms governing receptor availability for signalling
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批准号:nhmrc : GNT1146087
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项目类别:Project Grants
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资助金额:$52.7万
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财政年份:2018
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负责人:A/Pr Natasha Harvey
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依托单位:
Deciphering the transcriptional program that instructs lymphatic endothelial cell fate.
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批准号:nhmrc : GNT1107643
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项目类别:Project Grants
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资助金额:$54.2万
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财政年份:2016
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负责人:A/Pr Natasha Harvey
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依托单位:
Deciphering the transcriptional program that instructs lymphatic endothelial cell fate.
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批准号:nhmrc : 1107643
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项目类别:Project Grants
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资助金额:$37.16万
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财政年份:2016
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负责人:A/Pr Natasha Harvey
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依托单位:
Regulation of VEGFR trafficking and signal transduction by the ubiquitin ligase Nedd4
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批准号:nhmrc : 1083690
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项目类别:Project Grants
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资助金额:$25.9万
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财政年份:2015
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负责人:A/Pr Natasha Harvey
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依托单位:
Defining the role of GATA2 in lymphatic vascular development as a means to understanding how GATA2 mutations predispose to human lymphedema.
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批准号:nhmrc : 1061365
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项目类别:Project Grants
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资助金额:$47.94万
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财政年份:2014
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负责人:A/Pr Natasha Harvey
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依托单位:
Defining the role of the ubiquitin protein ligase Nedd4 in vascular development.
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批准号:nhmrc : 1027244
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项目类别:Project Grants
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资助金额:$46.82万
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财政年份:2012
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负责人:A/Pr Natasha Harvey
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依托单位:
Characterising signals important for lymphangiogenesis during development and disease.
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批准号:nhmrc : 1028388
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项目类别:Project Grants
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资助金额:$40.34万
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财政年份:2012
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负责人:A/Pr Natasha Harvey
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依托单位:
Defining the molecular events that initiate the genesis of lymphatic vessels.
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批准号:nhmrc : 626959
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项目类别:NHMRC Project Grants
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资助金额:$37.03万
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财政年份:2010
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负责人:A/Pr Natasha Harvey
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依托单位:
Molecular Mechanisms of Lymphangiogenesis in Development and Disease.
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批准号:nhmrc : 453493
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项目类别:NHMRC Project Grants
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资助金额:$20.26万
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财政年份:2007
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负责人:A/Pr Natasha Harvey
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依托单位:
国内基金
海外基金
PfAP2-R介导的PfCRT转录调控在恶性疟原虫对喹啉类药物抗性中的作用及机制研究
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批准号:82372275
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项目类别:面上项目
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资助金额:49.00万元
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批准年份:2023
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负责人:刘耀宝
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依托单位:
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项目类别:面上项目
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资助金额:49.00万元
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批准年份:2023
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依托单位: