Defining the role of the ubiquitin protein ligase Nedd4 in vascular development.
Defining the role of the ubiquitin protein ligase Nedd4 in vascular development.
批准号:
nhmrc : 1027244
负责人:
A/Pr Natasha Harvey
金额:
$46.82万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2012
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2012-01-01 至 2015-12-31
中文摘要
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英文摘要
Blood and lymphatic vessels are vital components of the cardiovascular system. Abnormalities in the growth and development of these vessels are associated with human disorders including cancer and cardiovascular disease. The focus of this application is to characterise the role of the ubiquitin protein ligase Nedd4 in vascular development, with the aim of identifying targets to which novel therapeutics for the treatment of blood and lymphatic vascular diseases could be generated.
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会议论文
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Defining the role of a novel transcriptional enhancer element in regulation of Prox1 expression and endothelial cell identity.
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