Defining the role of the ubiquitin protein ligase Nedd4 in vascular development.

定义泛素蛋白连接酶 Nedd4 在血管发育中的作用。

• 批准号: nhmrc : 1027244
• 负责人: A/Pr Natasha Harvey
• 金额: $ 46.82万
• 依托单位: University of South Australia
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/defining-role-ubiquitin-vascular-development/110552
• 关键词: Defining; role; ubiquitin; protein; ligase

Blood and lymphatic vessels are vital components of the cardiovascular system. Abnormalities in the growth and development of these vessels are associated with human disorders including cancer and cardiovascular disease. The focus of this application is to characterise the role of the ubiquitin protein ligase Nedd4 in vascular development, with the aim of identifying targets to which novel therapeutics for the treatment of blood and lymphatic vascular diseases could be generated.

血管和淋巴管是心血管系统的重要组成部分。这些血管的生长和发育异常与包括癌症和心血管疾病在内的人类疾病有关。本申请的重点是确定泛素蛋白连接酶Nedd4在血管发育中的作用，目的是鉴定可以产生用于治疗血液和淋巴管疾病的新疗法的靶标。