THERAPY AND PREVENTION OF PERIODONTAL DISEASES

牙周疾病的治疗和预防

• 批准号: 3963864
• 负责人: ROBERT J. GENCO
• 金额: --
• 依托单位: STATE UNIVERSITY OF NEW YORK AT BUFFALO
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3963864
• 关键词: antibiotics; bacterial antigens; chemotaxis; complement; dental disorder chemotherapy; dental disorder diagnosis; dental plaque; genetics; human subject; human therapy evaluation; human tissue; immunofluorescence technique; longitudinal human study; microorganism antigen; oral bacteria; periodontitis; periodontium disorder; physiologic bone resorption; preventive dentistry; radiotracer; tetracyclines

A. To develop and evaluate clinical measurements of periodontal diseases in order to more accurately measure small changes especially in periodontal attachment. B. To determine if therapy of gingivitis can be better accomplished by use of antiplaque agents along with mechanical debridement and personal plaque control. C. To determine if therapy of periodontitis can be more efficiently achieved with the use of antibiotics in addition to the standard therapeutic regime of debridement, surgery and plaque control. D. To determine if the use of antimicrobial or antibiotic therapy will result in better treatment of juvenile periodontitis (periodontosis). E. To determine the changes in bacterial flora associated with successful therapy as carried out above in B to D. F. To determine the changes in host response after therapy carried out according to A to C above. Specific host response measurements will include lymphocyte and neutrophil functions, as well as serum immunoglobulins, complement, and serum modulating factors which influence neutrophil and/or lymphocyte function. G. To determine the effects of behavioral aspects of motivation for bacterial plaque control in the treatment and maintenance after treatment of patients with periodontal disease. To this and it is proposed: (1) to identify social, behavioral, and attitudinal factors related to patient cooperation and improvement in periodontal therapy. (2) To develop and evaluate a structured interview for use in selecting patients for periodontal therapy and in selecting communication strategies for instructing individual patients in preventing procedures. (3) To develop and evaluate instructional approaches which are appropriate to the concerns and cognitive skill levels of various patients. H. To evaluate the use of antiplaque agents in primary and secondary prevention of periodontal diseases.

A. 开发和评估牙周病的临床测量 为了更准确地测量微小的变化，特别是牙周的变化 依恋。 B. 确定治疗牙龈炎是否可以更好 通过使用抗牙菌斑剂和机械清创来完成 和个人牙菌斑控制。 C. 确定是否治疗牙周炎 除了使用抗生素外，还可以更有效地实现 清创、手术和斑块的标准治疗方案 控制。 D. 确定是否使用抗菌药物或抗生素治疗 将更好地治疗青少年牙周炎（牙周病）。 E. 确定与成功相关的细菌菌群变化 治疗如上述 B 至 D.F. 中进行，以确定变化 根据上述 A 至 C 进行治疗后的宿主反应。 具体的宿主反应测量将包括淋巴细胞和中性粒细胞 功能，以及血清免疫球蛋白、补体和血清 影响中性粒细胞和/或淋巴细胞功能的调节因子。 G. 确定动机行为方面的影响 治疗中的菌斑控制和治疗后的维护 牙周病患者。 对此，建议： (1) 识别与患者相关的社会、行为和态度因素 牙周治疗的合作和改进。 (2) 开发和 评估用于选择患者的结构化访谈 牙周治疗以及选择沟通策略 指导个别患者预防手术。 (3) 发展 并评估适合所关注问题的教学方法 以及不同患者的认知技能水平。 H. 评估使用 抗牙菌斑剂在牙周一级和二级预防中的作用 疾病。