ORAL MICROBIOLOGY

口腔微生物学

• 批准号: 3963862
• 负责人: ROBERT J. GENCO
• 金额: --
• 依托单位: STATE UNIVERSITY OF NEW YORK AT BUFFALO
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3963862
• 关键词: Actinomyces; B lymphocyte; Bacteroides; Fusobacterium; Lactobacillus; Propionibacterium; Streptococcus; T lymphocyte; bacterial antigens; cellular immunity; chemotaxis; chronic disease /disorder; complement; dental disorder chemotherapy; dental disorder diagnosis; dental plaque; disease /disorder prevention /control; gel electrophoresis; gingivitis; human subject; human tissue; humoral immunity; immunoelectrophoresis; immunoglobulin A; immunoglobulin D; immunoglobulin E; immunoglobulin G; immunoglobulin M; immunoregulation; longitudinal human study; lymphokines; microorganism immunology; neutrophil; oral bacteria; osteoclasts; periodontium disorder; phagocytosis

A. To enumerate the predominant flora in periodontal pockets of patients with periodontitis and juvenile periodontitis (periodontosis). B. To develop methods for rapid identification and enumeration of pocket organisms with pathogenic potential by immunofluorescence, cultural and functional procedures. C. To determine the antibiotic sensitivity of the predominant flora and of the potentially periodontopathologic flora in periodontal pockets as an aid in the selection of appropriate antibiotics for therapy. D. To monitor changes in pocket flora with therapy as part of longitudinal studies of effectiveness of therapy over a long period of time. E. To monitor development of antibiotic resistance in the oral flora during antibiotic therapy. F. To attempt to eradicate candidate pathogens from the periodontal microflora and to assess the clinical effects of this procedure. G. To carry out taxonomic studies including biochemical, serological, genetic and other procedures as necessary to classify periodontal pathogens.

A.牙周袋内优势植物群的计数 牙周炎和青少年牙周炎（牙周病）。 B。到 制定快速识别和计数口袋的方法 通过免疫荧光、培养和 功能程序。 C.为了确定抗生素敏感性， 优势植物群和潜在的牙周病植物群， 牙周袋作为选择适当抗生素的辅助手段 治疗 D.监测治疗过程中囊袋植物群的变化， 长期治疗有效性的纵向研究， 时间 E.监测口腔植物群中抗生素耐药性的发展 在抗生素治疗期间。 F.试图根除候选病原体 从牙周菌群，并评估其临床效果， procedure. G.进行分类学研究，包括生物化学， 血清学、遗传学和其他必要的程序， 牙周病原体