ORAL MICROBIOLOGY

口腔微生物学

• 批准号: 4692784
• 负责人: ROBERT J. GENCO
• 金额: --
• 依托单位: STATE UNIVERSITY OF NEW YORK AT BUFFALO
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/4692784
• 关键词: Actinomyces; B lymphocyte; Bacteroides; Fusobacterium; Lactobacillus; Propionibacterium; Streptococcus; T lymphocyte; bacterial antigens; cellular immunity; chemotaxis; chronic disease /disorder; complement; dental disorder chemotherapy; dental disorder diagnosis; dental plaque; disease /disorder prevention /control; gel electrophoresis; gingivitis; human subject; human tissue; humoral immunity; immunoelectrophoresis; immunoglobulin A; immunoglobulin D; immunoglobulin E; immunoglobulin G; immunoglobulin M; immunoregulation; longitudinal human study; lymphokines; microorganism immunology; neutrophil; oral bacteria; osteoclasts; periodontium disorder; phagocytosis

A. To enumerate the predominant flora in periodontal pockets of patients with periodontitis and juvenile periodontitis (periodontosis). B. To develop methods for rapid identification and enumeration of pocket organisms with pathogenic potential by immunofluorescence, cultural and functional procedures. C. To determine the antibiotic sensitivity of the predominant flora and of the potentially periodontopathologic flora in periodontal pockets as an aid in the selection of appropriate antibiotics for therapy. D. To monitor changes in pocket flora with therapy as part of longitudinal studies of effectiveness of therapy over a long period of time. E. To monitor development of antibiotic resistance in the oral flora during antibiotic therapy. F. To attempt to eradicate candidate pathogens from the periodontal microflora and to assess the clinical effects of this procedure. G. To carry out taxonomic studies including biochemical, serological, genetic and other procedures as necessary to classify periodontal pathogens.

A. 列举患者牙周袋中的主要菌群 患有牙周炎和青少年牙周炎（牙周病）。 B、至 开发快速识别和计数口袋的方法 通过免疫荧光、培养和检测具有致病潜力的生物体 功能程序。 C. 确定抗生素敏感性 主要菌群和潜在的牙周病理菌群 牙周袋有助于选择合适的抗生素 用于治疗。 D. 将治疗作为监测口袋菌群变化的一部分 长期治疗效果的纵向研究 时间。 E. 监测口腔菌群抗生素耐药性的发展 抗生素治疗期间。 F. 尝试根除候选病原体 从牙周微生物区系中获取并评估其临床效果 程序。 G. 进行分类学研究，包括生物化学、 血清学、遗传学和其他必要的分类程序 牙周病原体。