PREDICTIVE VALUE OF THE EEG IN FEBRILE SEIZURES

脑电图对热性惊厥的预测价值

• 批准号: 3846200
• 负责人: S E EMOTO
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3846200
• 关键词: Bosnia-Hercegovina; child (0-11); clinical trials; diagnosis design /evaluation; disease /disorder proneness /risk; electroencephalography; febrile seizure; human morbidity; human subject; information systems; longitudinal human study; nervous system disorder diagnosis; prognosis; relapse /recurrence; statistics /biometry

This population-based study will evaluate the significance of the EEG as a predictor for recurrence of seizures in those children who have had a simple febrile convulsion. Outcomes reported are febrile seizure recurrence and afebrile seizure occurrence. The evolution of the EEG pattern will be described, and patterns will be correlated with the clinical outcome. The clinical study was carried out in Skopje, Macedonia (Yugoslavia), at the Pediatric Clinic of the University of Skopje. The study began in FY 1982. Patient accrual was completed in December, 1984, by which time approximately 400 patients with a febrile seizure, no prior complex or multiple seizures and with a normal or nonspecific abnormal EEG, were registered into the study and began the study protocol and follow-up. An additional 300 patients with a specific abnormal EEG were entered for baseline information and follow-up. Additional efforts by the clinical center were needed to collect data from those patients lacking a return visit and those who did not have long term follow-up. Final follow-up visits were completed in FY 1991. Data editing and file creation are complete. Statistical analysis of baseline EEG and its association with characteristics of the child and family and the clinical characteristics of the seizure has been published. Analysis is currently being conducted to examine: the effectiveness of the initial EEG in predicting recurrent febrile seizures; the evolution of EEGs in children with febrile seizures; and the value of changes in EEGs in predicting febrile seizure recurrence. In addition, information on comorbidity is being extracted from the original forms for future assessment.

这项基于人群的研究将评估EEG的重要性， 一个预测复发的癫痫发作的儿童谁有一个 单纯性热性惊厥 报告的结局为热性惊厥 复发和无热性惊厥发生。 脑电图的演变 将描述图案，并且图案将与图案相关联。 临床结果。 临床研究在斯科普里进行， 马其顿（南斯拉夫），马其顿大学儿科诊所 斯科普里。 这项研究始于1982财政年度。 患者招募于12月完成， 1984年，到那时大约有400名热性惊厥患者，没有 既往复杂或多发性癫痫发作，并伴有正常或非特异性 异常EEG，登记入研究并开始研究方案 和后续行动。 另外300名患者有特定的异常脑电图 用于基线信息和随访。 更多努力 临床中心需要收集这些患者的数据 缺乏回访和没有长期随访的患者。 最后的后续访问于1991财政年度完成。 数据编辑和文件 创造已经完成。 基线脑电图的统计学分析及其意义 与儿童和家庭特征以及临床特征的相关性 已公布检获物品的特征。 分析目前 正在进行检查：初始EEG的有效性， 预测复发性热性惊厥;儿童脑电图的演变 热性惊厥;脑电图的变化在预测 热性惊厥复发 此外，还提供了关于科摩罗的资料， 从原始表格中提取，以供将来评估。