PREDICTIVE VALUE OF THE EEG IN FEBRILE SEIZURES

脑电图对热性惊厥的预测价值

• 批准号: 3881727
• 负责人: S E EMOTO
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3881727
• 关键词: Bosnia-Hercegovina; child (0-11); diagnosis design /evaluation; disease /disorder proneness /risk; electroencephalography; febrile seizure; human morbidity; human subject; information systems; longitudinal human study; pediatrics; prognosis; relapse /recurrence; statistics /biometry

This population based study will evaluate the significance of the EEG as a predictor for recurrence of seizures in those children who have had a simple febrile convulsion. Outcomes reported are febrile seizure recurrence and afebrile seizure occurrence. The evolution of the EEG pattern will be described, and patterns will be correlated with the clinical outcome. The clinical study is being carried out in Skopje, Yugoslavia, at the Pediatric Clinic of the University of Skopje. The study began in FY 1982 and final follow-up visits will be completed in FY 1991. Patient accrual was completed in December, 1984, by which time approximately 400 patients with a febrile seizure, no prior complex or multiple seizures and with a normal or nonspecific abnormal EEG, were registered into the study and began the study protocol and follow-up. An additional 300 patients with a specific abnormal EEG were entered for baseline information and follow-up. Data editing and file creation are continuing. After an on-site review visit, it was determined that additional efforts by the clinical center were needed to collect data from those patients lacking a return visit and those who did not have return visits after 24 months following study entry. This will facilitate study of long-term recurrence of febrile seizures, change in EEG, and the predictive qualities of EEG for febrile seizure occurrence. The extended follow-up effort is now in progress. Statistical analysis of baseline EEG and its association with characteristics of the child and family and the clinical characteristics of the seizure has been completed and a manuscript has been submitted for publication. The master file, including follow-up data at all visits for all patients, should be completed in FY 1991, at which time further analyses will be undertaken.

这项以人群为基础的研究将评估EEG作为一种 癫痫发作复发的预测因子 单纯性热性惊厥。报道的结果是发热性癫痫复发 以及无热性惊厥发生。脑电模式的演变将是 描述，并且模式将与临床结果相关。这个 临床研究正在南斯拉夫斯科普里的儿科医院进行。 斯科普里大学诊所。 这项研究于1982财年开始，最后的后续访问将于#年完成。 1991财年。病人应计于1984年12月完成，到那时 大约400名有发热性癫痫的患者，既往无复杂症状或 多次癫痫发作，脑电正常或非特异性异常 登记入研究并开始研究方案和随访。一个 另外300名有特定异常脑电的患者入选 基线信息和后续行动。数据编辑和文件创建是 还在继续。经过现场考察，确定 临床中心还需要付出更多努力才能从 没有回访的病人和没有回访的病人 在进入学习后24个月后访问。这将有助于研究 高热惊厥的长期复发、脑电改变和预测 高热惊厥发生时的脑电特征。延长的随访时间 目前，这一努力正在进行中。基线脑电及其相关参数的统计分析 儿童及其家庭特征与临床的关系 扣押的特征已经完成，手稿已经完成 已提交供出版。主文件，包括所有的后续数据 对所有患者的探视，应在1991财年完成，届时 将进行进一步的分析。