PREDICTIVE VALUE OF THE EEG IN FEBRILE SEIZURES

脑电图对热性惊厥的预测价值

• 批准号: 3782333
• 负责人: S E EMOTO
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3782333
• 关键词: Bosnia-Hercegovina; child (0-11); clinical trials; disease /disorder proneness /risk; electroencephalography; febrile seizure; human morbidity; human subject; longitudinal human study; nervous system disorder diagnosis; nervous system disorder epidemiology; patient /disease registry; prognosis; relapse /recurrence; statistics /biometry

This population-based study will evaluate the significance of the EEG as a predictor for recurrence of seizures in those children who have had a simple febrile convulsion. Outcomes reported are febrile seizure recurrence and afebrile seizure occurrence. The evolution of the EEG pattern will be described, and patterns will be correlated with the clinical outcome. The clinical study was carried out in Skopje, Macedonia (Yugoslavia), at the Pediatric Clinic of the University of Skopje. The study began in FY 1982. Patient accrual was completed in December, 1984, by which time approximately 400 patients with a febrile seizure, no prior complex or multiple seizures and with a normal or nonspecific abnormal EEG, were registered into the study and began the study protocol and follow-up. An additional 300 patients with a specific abnormal EEG were entered for baseline information and follow-up. Additional efforts by the clinical center were needed to collect data from those patients lacking a return visit and those who did not have long term follow-up. Final follow-up visits were completed in FY 1991. Initially 22% of the 676 children had an EEG classified as paroxysmally abnormal, which was associated by logistic regression analysis with older age, number of previous febrile seizures, preexisting motor abnormality, and focal index seizures. Statistical analysis of baseline EEG and its association with characteristics of the child and family, and the clinical characteristics of the seizure has been published. Analysis is currently being conducted to examine: the effectiveness of the initial EEG in predicting recurrent febrile seizures; the evolution of EEGs in children with febrile seizures; and the value of changes in EEGs in predicting febrile seizure recurrence. Among the more than 76% who were followed for an average of 29 months, one-fourth experienced at least one recurrent febrile seizure. The recurrence rate was 25%, 24%, and 23%, respectively, for those with normal, nonspecifically abnormal, and specifically abnormal initial EEGs. Initial EEG was also not predictive of multiple recurrences. The classification of EEG at presentation was not related to the likelihood of recurrence of febrile seizures. Additional publications from this project will be reported under ZO1 NS 02652-09 (Statistical Collaboration and Consultation).

这项基于人群的研究将评估EEG的重要性， 一个预测复发的癫痫发作的儿童谁有一个 单纯性热性惊厥 报告的结局为热性惊厥 复发和无热性惊厥发生。 脑电图的演变 将描述图案，并且图案将与图案相关联。 临床结果。 临床研究在斯科普里进行， 马其顿（南斯拉夫），马其顿大学儿科诊所 斯科普里。 这项研究始于1982财政年度。 患者招募于12月完成， 1984年，到那时大约有400名热性惊厥患者，没有 既往复杂或多发性癫痫发作，并伴有正常或非特异性 异常EEG，登记入研究并开始研究方案 和后续行动。 另外300名患者有特定的异常脑电图 用于基线信息和随访。 更多努力 临床中心需要收集这些患者的数据 缺乏回访和没有长期随访的患者。 最后的后续访问于1991财政年度完成。 最初，22%的 676名儿童的脑电图被归类为阵发性异常， Logistic回归分析显示， 既往热性惊厥、既存运动异常和病灶指数 癫痫发作 基线EEG的统计分析及其与 儿童和家庭的特点，以及临床特点 已经公布了 目前正在进行分析 检查：初始EEG预测复发的有效性 热性惊厥;热性惊厥患儿脑电图的演变; 脑电图变化对热性惊厥复发的预测价值。 在超过76%的人中，平均随访时间为29个月， 四分之一的人至少经历过一次反复发热性惊厥。 的 复发率分别为25%、24%和23%， 正常、非特异性异常和特异性异常的初始EEG。 初始EEG也不能预测多发性复发。 的 在介绍EEG的分类是不相关的可能性， 热性惊厥复发。 本项目的其他出版物 将根据ZO 1 NS 02652-09（统计协作和 协商）。