PREDICTIVE VALUE OF THE EEG IN FEBRILE SEIZURES

脑电图对热性惊厥的预测价值

• 批准号: 3860801
• 负责人: S E EMOTO
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3860801
• 关键词: Bosnia-Hercegovina; child (0-11); clinical trials; diagnosis design /evaluation; disease /disorder proneness /risk; electroencephalography; febrile seizure; human morbidity; human subject; information systems; longitudinal human study; prognosis; relapse /recurrence; statistics /biometry

This population-based study will evaluate the significance of the EEG as a predictor for recurrence of seizures in those children who have had a simple febrile convulsion. Outcomes reported are febrile seizure recurrence and afebrile seizure occurrence. The evolution of the EEG pattern will be described, and patterns will be correlated with the clinical outcome. The clinical study is being carried out in Skopje, Yugoslavia, at the Pediatric Clinic of the University of Skopje. The study began in FY 1982 and final follow-up visits were completed in FY 1991. Patient accrual was completed in December, 1984, by which time approximately 400 patients with a febrile seizure, no prior complex or multiple seizures and with a normal or nonspecific abnormal EEC, were registered into the study and began the study protocol and follow-up. An additional 300 patients with a specific abnormal EEG were entered for baseline information and followup. After an on-site review visit, it was determined that additional efforts by the clinical center were needed to collect data from those patients lacking a return visit and those who did not have return visits after 24 months following study entry. The extended follow-up effort has been completed. Data editing and file creation are complete. Statistical analysis of baseline EEG and its association with characteristics of the child and family and the clinical characteristics of the seizure has been completed and a manuscript has been accepted for publication. A report on the relationship of initial EEG to recurrence risk is in progress.

这项以人群为基础的研究将评估脑电的重要性，如 儿童癫痫发作复发的预测因子 单纯性热性惊厥。报道的结果是发热性癫痫 复发和无热性惊厥发生。脑电的发展历程 模式将被描述，并且模式将与 临床结果。这项临床研究正在斯科普里进行， 南斯拉夫，斯科普里大学儿科诊所。 这项研究始于1982财年，最后一次跟踪访问于#年完成。 1991财年。病人应计于1984年12月完成，到那时 大约400名有发热性癫痫的患者，既往无复杂症状或 多次癫痫发作，EEC正常或非特异性异常 登记入研究并开始研究方案和随访。一个 另外300名有特定异常脑电的患者入选 基线信息和后续行动。在实地考察后， 确定临床中心需要付出更多努力才能 收集那些没有回访的患者和那些回访的患者的数据 在学习后24个月内没有回访。这个 已经完成了长期的后续工作。数据编辑和文件 创造完成了。基线脑电及其相关参数的统计分析 儿童及其家庭特征与临床的关系 扣押的特征已经完成，一份手稿 已被接受出版。一篇关于声母关系的报告 脑电对复发风险的评估正在进行中。