课题基金 / 基金详情

NATURAL HISTORY AND TREATMENT OF CHRONIC NON-A, NON-B HEPATITIS

NATURAL HISTORY AND TREATMENT OF CHRONIC NON-A, NON-B HEPATITIS
慢性非甲、非乙型肝炎的自然史和治疗
批准号：
3855407
负责人：
E A JONES
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3855407
关键词：
antiviral agents chronic disease /disorder clinical trials dosage hepatitis C virus human subject human therapy evaluation human tissue interferons liver disorder chemotherapy liver pharmacology longitudinal human study microorganism disease chemotherapy pathologic process ribavirin serology /serodiagnosis transaminases virus RNA

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中文摘要
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英文摘要
Patients with well-documented chronic non-A, non-B hepatitis are being evaluated to determine the long-term natural history of this common form of chronic liver disease. A cohort of such patients are available to evaluate experimental therapies. Previous studies have shown that alpha interferon therapy has a short-term beneficial effect in approximately 50% of patients during treatment and that the beneficial response is sustained in approximately 20% after stopping interferon. A pilot study of ribavirin therapy has been conducted in 14 patients with chronic hepatitis C. Serum aminotransferases decreased during therapy in all patients and became normal in 5 (36%). Serum levels of HCV RNA also decreased significantly during therapy.
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会议论文
STUDIES OF THE OPIATE SYSTEM IN CHOLESTATIC LIVER DISEASE
TRIALS OF THERAPIES FOR PRIMARY BILLIARY CIRRHOSIS
CONTROLLED TRIAL OF CHLORAMBUCIL THERAPY IN PRIMARY BILIARY CIRRHOSIS
STUDIES OF THE NATURAL HISTORY AND TREATMENT OF CHRONIC TYPE B HEPATITIS