STUDIES OF THE NATURAL HISTORY AND TREATMENT OF DUCK HEPATITIS B VIRUS INFECTION

鸭乙型肝炎病毒感染自然史及治疗的研究

• 批准号: 3918255
• 负责人: E A JONES
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3918255
• 关键词: antiviral agents; chronic disease /disorder; disease /disorder model; duck hepatitis B virus; ducks; hepatitis B; immunopharmacology; liver disorder chemotherapy; liver neoplasms; medical complication; virus replication

There are many similarities in structure and properties between the human hepatitis B virus (HBV) and the duck hepatitis B virus (DHBV). These similarities suggest that DHBV infection in ducks may be a useful experimental model of human HBV infection, particularly as HBV cannot be grown readily in cell culture. Ducks infected with DHBV at birth become chronic carriers of the virus, although they may not develop overt hepatitis. Some DHBV-infected ducks have been reported to develop hepatocellular carcinoma, a tumor strongly linked etiologically in humans with chronic hepatitis B infection. As a screening test for new effective therapies for chronic type B hepatitis in man, new antiviral immunomodulatory agents are being assessed for their ability to suppress DHBV replication in ducks.

两者在结构和性质上有许多相似之处